Effect of Bariatric Weight Loss on the Adipose Lipolytic Transcriptome in Obese Humans
Joint Authors
Karki, Shakun
Farb, Melissa G.
Myers, Samantha
Apovian, Caroline
Hess, Donald T.
Gokce, Noyan
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Dysregulated lipolysis has been implicated in mechanisms of cardiometabolic disease and inflammation in obesity.
Purpose.
We sought to examine the effect of bariatric weight loss on adipose tissue lipolytic gene expression and their relationship to systemic metabolic parameters in obese subjects.
Methods/Results.
We biopsied subcutaneous adipose tissue in 19 obese individuals (BMI 42 ± 5 kg/m2, 79% female) at baseline and after a mean period of 8 ± 5 months (range 3–15 months) following bariatric surgery.
We performed adipose tissue mRNA expression of proteins involved in triglyceride hydrolysis and correlated their weight loss induced alterations with systemic parameters associated with cardiovascular disease risk.
mRNA transcripts of adipose triglyceride lipase (ATGL), hormone-sensitive lipase (HSL), and lipid droplet proteins comparative gene identification 58 (CGI-58) and perilipin increased significantly after weight loss (p<0.05 for all).
ATGL expression correlated inversely with plasma triglyceride (TG), hemoglobin A1C (HbA1C), and glucose, and HSL expression correlated negatively with glucose, while CGI-58 was inversely associated with HbA1C.
Conclusion.
We observed increased expression of adipose tissue lipolytic genes following bariatric weight loss which correlated inversely with systemic markers of lipid and glucose metabolism.
Functional alterations in lipolysis in human adipose tissue may play a role in shaping cardiometabolic phenotypes in human obesity.
American Psychological Association (APA)
Karki, Shakun& Farb, Melissa G.& Myers, Samantha& Apovian, Caroline& Hess, Donald T.& Gokce, Noyan. 2015. Effect of Bariatric Weight Loss on the Adipose Lipolytic Transcriptome in Obese Humans. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072115
Modern Language Association (MLA)
Karki, Shakun…[et al.]. Effect of Bariatric Weight Loss on the Adipose Lipolytic Transcriptome in Obese Humans. Mediators of Inflammation No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1072115
American Medical Association (AMA)
Karki, Shakun& Farb, Melissa G.& Myers, Samantha& Apovian, Caroline& Hess, Donald T.& Gokce, Noyan. Effect of Bariatric Weight Loss on the Adipose Lipolytic Transcriptome in Obese Humans. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072115
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072115