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3,5,4′-Tri-O-acetylresveratrol Attenuates Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome via MAPKSIRT1 Pathway
Joint Authors
Nan, Yandong
Ma, Lijie
Zhao, Yilin
Wang, Ruixuan
Chen, Tingting
Li, Wangping
Jin, Faguang
Liu, Xueying
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-16
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The aim of the present research was to investigate the protecting effects of 3,5,4′-tri-O-acetylresveratrol (AC-Rsv) on LPS-induced acute respiratory distress syndrome (ARDS).
Lung injuries have been evaluated by histological examination, wet-to-dry weight ratios, and cell count and protein content in bronchoalveolar lavage fluid.
Inflammation was assessed by MPO activities and cytokine secretion in lungs and cells.
The results showed that AC-Rsv significantly reduced the mortality of mice stimulated with LPS.
Pretreatment of AC-Rsv attenuated LPS-induced histological changes, alleviated pulmonary edema, reduced blood vascular leakage, and inhibited the MPO activities in lungs.
What was more, AC-Rsv and Rsv treatment reduced the secretion of TNF-α, IL-6, and IL-1β in lungs and NR8383 cells, respectively.
Further exploration revealed that AC-Rsv and Rsv treatment relieved LPS-induced inhibition on SIRT1 expression and restrained the activation effects of LPS on MAPKs and NF-κB activation both in vitro and in vivo.
More importantly, in vivo results have also demonstrated that the protecting effects of Rsv on LPS-induced inflammation would be neutralized when SIRT1 was in-hibited by EX527.
Taken together, these results indicated that AC-Rsv protected lung tissue against LPS-induced ARDS by attenuating inflammation via p38 MAPK/SIRT1 pathway.
American Psychological Association (APA)
Ma, Lijie& Zhao, Yilin& Wang, Ruixuan& Chen, Tingting& Li, Wangping& Nan, Yandong…[et al.]. 2015. 3,5,4′-Tri-O-acetylresveratrol Attenuates Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome via MAPKSIRT1 Pathway. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1072146
Modern Language Association (MLA)
Ma, Lijie…[et al.]. 3,5,4′-Tri-O-acetylresveratrol Attenuates Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome via MAPKSIRT1 Pathway. Mediators of Inflammation No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1072146
American Medical Association (AMA)
Ma, Lijie& Zhao, Yilin& Wang, Ruixuan& Chen, Tingting& Li, Wangping& Nan, Yandong…[et al.]. 3,5,4′-Tri-O-acetylresveratrol Attenuates Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome via MAPKSIRT1 Pathway. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1072146
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072146