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T Regulatory and T Helper 17 Cells in Primary Sjögren’s Syndrome: Facts and Perspectives
Joint Authors
Carubbi, Francesco
Bartoloni, Elena
Mirabelli, Giulia
Cannarile, Francesca
Cipriani, Paola
Giacomelli, Roberto
Gerli, Roberto
Caterbi, Sara
Alunno, Alessia
Bistoni, Onelia
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Historically, primary Sjögren’s syndrome (pSS) was thought to be a T helper (h) 1 driven disease due to the predominance of CD4+T lymphocytes and their products in target organs and peripheral blood of patients.
In the last decades, the identification of a number of T cell subsets, including Th17, T regulatory (Treg), and follicular helper T cells, challenged this long-standing paradigm and prompted to identify their role in pSS pathogenesis.
In addition the impact of abnormal proinflammatory cytokine production, such as IL-6, IL-17, IL-22, and IL-23, has also attracted considerable attention.
However, although several studies have been carried out in experimental models and patients with pSS, many aspects concerning the role of Treg cells and IL-17/Th17 cell system in pSS pathogenesis are not fully elucidated.
In particular, the role played by different IL-17-producing T cell subsets as well as the effects of pharmacological therapies on Treg/Th17 cell balance represents an intriguing issue.
The aim of this review article is to provide an overview of current knowledge on Treg cells and IL-17-producing T cells in pSS pathogenesis.
We believe that these insights into pSS pathogenesis may provide the basis for successful therapeutic intervention in this disease.
American Psychological Association (APA)
Alunno, Alessia& Carubbi, Francesco& Bistoni, Onelia& Caterbi, Sara& Bartoloni, Elena& Mirabelli, Giulia…[et al.]. 2015. T Regulatory and T Helper 17 Cells in Primary Sjögren’s Syndrome: Facts and Perspectives. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072198
Modern Language Association (MLA)
Alunno, Alessia…[et al.]. T Regulatory and T Helper 17 Cells in Primary Sjögren’s Syndrome: Facts and Perspectives. Mediators of Inflammation No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1072198
American Medical Association (AMA)
Alunno, Alessia& Carubbi, Francesco& Bistoni, Onelia& Caterbi, Sara& Bartoloni, Elena& Mirabelli, Giulia…[et al.]. T Regulatory and T Helper 17 Cells in Primary Sjögren’s Syndrome: Facts and Perspectives. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072198
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072198