Impact of Inflammation on Myeloproliferative Neoplasm Symptom Development
Joint Authors
Geyer, Holly L.
Dueck, Amylou C.
Scherber, Robyn M.
Mesa, Ruben A.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Myeloproliferative neoplasms (essential thrombocythemia, ET; polycythemia vera, PV; myelofibrosis, MF) are monoclonal malignancies associated with genomic instability, dysregulated signaling pathways, and subsequent overproduction of inflammatory markers.
Acknowledged for their debilitating symptom profiles, recent investigations have aimed to determine the identity of these markers, the upstream sources stimulating their development, their prevalence within the MPN population, and the role they play in symptom development.
Creation of dedicated Patient Reported Outcome (PRO) tools, in combination with expanded access to cytokine analysis technology, has resulted in a surge of investigations evaluating the potential associations between symptoms and inflammation.
Emerging data demonstrates clear relationships between individual MPN symptoms (fatigue, abdominal complaints, microvascular symptoms, and constitutional symptoms) and cytokines, particularly IL-1, IL-6, IL-8, and TNF-α.
Information is also compiling on the role symptoms paradoxically play in the development of cytokines, as in the case of fatigue-driven sedentary lifestyles.
In this paper, we explore the symptoms inherent to the MPN disorders and the potential role inflammation plays in their development.
American Psychological Association (APA)
Geyer, Holly L.& Dueck, Amylou C.& Scherber, Robyn M.& Mesa, Ruben A.. 2015. Impact of Inflammation on Myeloproliferative Neoplasm Symptom Development. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072232
Modern Language Association (MLA)
Geyer, Holly L.…[et al.]. Impact of Inflammation on Myeloproliferative Neoplasm Symptom Development. Mediators of Inflammation No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1072232
American Medical Association (AMA)
Geyer, Holly L.& Dueck, Amylou C.& Scherber, Robyn M.& Mesa, Ruben A.. Impact of Inflammation on Myeloproliferative Neoplasm Symptom Development. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072232
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072232