Elevated Serum Tryptase and Endothelin in Patients with ST Segment Elevation Myocardial Infarction: Preliminary Report
Joint Authors
Siebert, Janusz
Lewicki, Lukasz
Marek-Trzonkowska, Natalia
Masiewicz, Emilia
Kolinski, Tomasz
Reiwer-Gostomska, Magdalena
Targonski, Radoslaw
Trzonkowski, Piotr
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
An inflammatory response plays a crucial role in myocardial damage after an acute myocardial infarction.
Objectives.
To measure serum concentrations of several mediators in patients with an acute myocardial infarction (STEMI) and to assess their potential relationship with a risk of coronary instability.
Patients and Methods.
The 33 patients with STEMI and 19 healthy volunteers were analyzed.
The clinical data were obtained; as well serum concentrations of tryptase, endothelin (ET-1), angiogenin, soluble c-kit, and PDGF were measured.
Results.
Patients with STEMI had higher serum tryptase and ET-1 than healthy volunteers (2,5 ± 0,4 ng/mL versus 1,1 ± 0,4 ng/mL and 0,7 ± 0,1 ng/mL versus 0,3 ± 0,1 ng/mL, resp.).
Subjects with significant lesion in left anterior descending artery (LAD) had lower serum ET-1 compared to those with normal LAD (0,6 ± 0,2 pg/mL versus 0,9 ± 0,4 pg/mL).
Patients with three-vessel coronary artery disease (CAD) had higher level of soluble c-kit compared to those with one- or two-vessel CAD: 19,9 ± 24,1 ng/mL versus 5,6 ± 1,9 ng/mL.
Conclusions.
Elevated serum tryptase and ET-1 may be markers of increased coronary instability; some cytokines may be related to the extension of CAD.
American Psychological Association (APA)
Lewicki, Lukasz& Siebert, Janusz& Marek-Trzonkowska, Natalia& Masiewicz, Emilia& Kolinski, Tomasz& Reiwer-Gostomska, Magdalena…[et al.]. 2015. Elevated Serum Tryptase and Endothelin in Patients with ST Segment Elevation Myocardial Infarction: Preliminary Report. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072303
Modern Language Association (MLA)
Lewicki, Lukasz…[et al.]. Elevated Serum Tryptase and Endothelin in Patients with ST Segment Elevation Myocardial Infarction: Preliminary Report. Mediators of Inflammation No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1072303
American Medical Association (AMA)
Lewicki, Lukasz& Siebert, Janusz& Marek-Trzonkowska, Natalia& Masiewicz, Emilia& Kolinski, Tomasz& Reiwer-Gostomska, Magdalena…[et al.]. Elevated Serum Tryptase and Endothelin in Patients with ST Segment Elevation Myocardial Infarction: Preliminary Report. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072303
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072303