CNTNAP3 Associated ATG16L1 Expression and Crohn’s Disease

Abstract EN

Autophagy is a common physiological process in cell homeostasis and regulation.

Autophagy-related gene mutations and autophagy disorders are important in Crohn’s disease (CD).

The nucleotide oligomerization domain 2–autophagy genes autophagy 16-like 1 (NOD2–ATG16L1) signaling axis disorder contributes to the dysfunction of autophagy.

This paper is focused on the relationship between contactin associated protein-like 3 (CNTNAP3) and ATG16L1 expression in Crohn’s disease.

The results indicated that the expression of ATG16L1 is higher in some CD patients compared to normal controls.

ATG16L1 was well correlated with the C-reactive protein (CRP) in some CD patients.

In vitro study revealed that CNTNAP3 could upregulate the expression of ATG16L1 and increase autophagy vacuoles.