Inflammation as a Driver of Clonal Evolution in Myeloproliferative Neoplasm
Author
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Our understanding of inflammation’s role in the pathogenesis of myeloproliferative neoplasm (MPN) is evolving.
The impact of chronic inflammation, a characteristic feature of MPN, likely goes far beyond its role as a driver of constitutional symptoms.
An inflammatory response to the neoplastic clone may be responsible for some pathologic aspects of MPN.
Moreover, JAK2V617F mutated hematopoietic stem and progenitor cells are resistant to inflammation, and this gives the neoplastic clone a selective advantage allowing for its clonal expansion.
Because inflammation plays a central role in MPN inflammation is a logical therapeutic target in MPN.
American Psychological Association (APA)
Fleischman, Angela G.. 2015. Inflammation as a Driver of Clonal Evolution in Myeloproliferative Neoplasm. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1072449
Modern Language Association (MLA)
Fleischman, Angela G.. Inflammation as a Driver of Clonal Evolution in Myeloproliferative Neoplasm. Mediators of Inflammation No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1072449
American Medical Association (AMA)
Fleischman, Angela G.. Inflammation as a Driver of Clonal Evolution in Myeloproliferative Neoplasm. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1072449
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072449