Circulating Irisin Levels Are Not Regulated by Nutritional Status, Obesity, or Leptin Levels in Rodents
Joint Authors
Folgueira, Cintia
Quiñones, Mar
Sánchez-Rebordelo, Estrella
Al-Massadi, Omar
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Irisin is a cleaved and secreted fragment of fibronectin type III domain containing 5 (FNDC5) that is mainly released by skeletal muscle and was proposed to mediate the beneficial effects of exercise on metabolism.
In the present study we aim to investigate the regulation of the circulating levels of irisin in obese animal models (diet-induced obese (DIO) rats and leptin-deficient (ob/ob) mice), as well as the influence of nutritional status and leptin.
Irisin levels were measured by Enzyme-Linked Immunosorbent Assay (ELISA) and Radioimmunoassay (RIA).
Serum irisin levels remained unaltered in DIO rats and ob/ob mice.
Moreover, its circulating levels were also unaffected by fasting, leptin deficiency, and exogenous leptin administration in rodents.
In spite of these negative results we find a negative correlation between irisin and insulin in DIO animals and a positive correlation between irisin and glucose under short-term changes in nutritional status.
Our findings indicate that serum irisin levels are not modulated by different physiological settings associated to alterations in energy homeostasis.
These results suggest that in rodents circulating levels of irisin are not involved in the pathophysiology of obesity and could be unrelated to metabolic status; however, further studies should clarify its precise role in states of glucose homeostasis imbalance.
American Psychological Association (APA)
Quiñones, Mar& Folgueira, Cintia& Sánchez-Rebordelo, Estrella& Al-Massadi, Omar. 2015. Circulating Irisin Levels Are Not Regulated by Nutritional Status, Obesity, or Leptin Levels in Rodents. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072460
Modern Language Association (MLA)
Quiñones, Mar…[et al.]. Circulating Irisin Levels Are Not Regulated by Nutritional Status, Obesity, or Leptin Levels in Rodents. Mediators of Inflammation No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1072460
American Medical Association (AMA)
Quiñones, Mar& Folgueira, Cintia& Sánchez-Rebordelo, Estrella& Al-Massadi, Omar. Circulating Irisin Levels Are Not Regulated by Nutritional Status, Obesity, or Leptin Levels in Rodents. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072460
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072460