NLRP3 Inflammasome: Activation and Regulation in Age-Related Macular Degeneration
Joint Authors
Gao, Jiangyuan
Liu, Ruozhou Tom
Cao, Sijia
Cui, Jing Z.
Wang, Aikun
To, Eleanor
Matsubara, Joanne A.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Age-related macular degeneration (AMD) is the leading cause of legal blindness in the elderly in industrialized countries.
AMD is a multifactorial disease influenced by both genetic and environmental risk factors.
Progression of AMD is characterized by an increase in the number and size of drusen, extracellular deposits, which accumulate between the retinal pigment epithelium (RPE) and Bruch’s membrane (BM) in outer retina.
The major pathways associated with its pathogenesis include oxidative stress and inflammation in the early stages of AMD.
Little is known about the interactions among these mechanisms that drive the transition from early to late stages of AMD, such as geographic atrophy (GA) or choroidal neovascularization (CNV).
As part of the innate immune system, inflammasome activation has been identified in RPE cells and proposed to be a causal factor for RPE dysfunction and degeneration.
Here, we will first review the classic model of inflammasome activation, then discuss the potentials of AMD-related factors to activate the inflammasome in both nonocular immune cells and RPE cells, and finally introduce several novel mechanisms for regulating the inflammasome activity.
American Psychological Association (APA)
Gao, Jiangyuan& Liu, Ruozhou Tom& Cao, Sijia& Cui, Jing Z.& Wang, Aikun& To, Eleanor…[et al.]. 2015. NLRP3 Inflammasome: Activation and Regulation in Age-Related Macular Degeneration. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072514
Modern Language Association (MLA)
Gao, Jiangyuan…[et al.]. NLRP3 Inflammasome: Activation and Regulation in Age-Related Macular Degeneration. Mediators of Inflammation No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1072514
American Medical Association (AMA)
Gao, Jiangyuan& Liu, Ruozhou Tom& Cao, Sijia& Cui, Jing Z.& Wang, Aikun& To, Eleanor…[et al.]. NLRP3 Inflammasome: Activation and Regulation in Age-Related Macular Degeneration. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072514
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072514