Nutritional Recovery with a Soybean Diet after Weaning Reduces Lipogenesis but Induces Inflammation in the Liver in Adult Rats Exposed to Protein Restriction during Intrauterine Life and Lactation
Joint Authors
Kawashita, Nair H.
Veloso, Roberto V.
Ignacio-Souza, Letícia Martins
Reis, Silvia Regina de Lima
Reis, Marise Auxiliadora de Barros
Latorraca, Márcia Queiroz
Arantes, Vanessa Cristina
Feres, Naoel Hassan
Colodel, Edson Moleta
Botosso, Bárbara Laet
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-29
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
We evaluated the effects of postweaning nutritional recovery with a soybean flour diet on de novo hepatic lipogenesis and inflammation in adult rats exposed to protein restriction during intrauterine life and lactation.
Rats from mothers fed with protein (casein) in a percentage of 17% (control, C) or 6% (low, L) during pregnancy and lactation were fed with diet that contained 17% casein (CC and LC groups, resp.) or soybean (CS and LS groups, resp.) after weaning until 90 days of age.
LS and CS rats had low body weight, normal basal serum triglyceride levels, increased ALT concentrations, and high HOMA-IR indices compared with LC and CC rats.
The soybean diet reduced PPARγ as well as malic enzyme and citrate lyase contents and activities.
The lipogenesis rate and liver fat content were lower in LS and CS rats relative to LC and CC rats.
TNFα mRNA and protein levels were higher in LS and CS rats than in LC and CC rats.
NF-κB mRNA levels were lower in the LC and LS groups compared with the CC and LC groups.
Thus, the soybean diet prevented hepatic steatosis at least in part through reduced lipogenesis but resulted in TNFα-mediated inflammation.
American Psychological Association (APA)
Reis, Silvia Regina de Lima& Feres, Naoel Hassan& Ignacio-Souza, Letícia Martins& Veloso, Roberto V.& Arantes, Vanessa Cristina& Kawashita, Nair H.…[et al.]. 2015. Nutritional Recovery with a Soybean Diet after Weaning Reduces Lipogenesis but Induces Inflammation in the Liver in Adult Rats Exposed to Protein Restriction during Intrauterine Life and Lactation. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1072550
Modern Language Association (MLA)
Reis, Silvia Regina de Lima…[et al.]. Nutritional Recovery with a Soybean Diet after Weaning Reduces Lipogenesis but Induces Inflammation in the Liver in Adult Rats Exposed to Protein Restriction during Intrauterine Life and Lactation. Mediators of Inflammation No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1072550
American Medical Association (AMA)
Reis, Silvia Regina de Lima& Feres, Naoel Hassan& Ignacio-Souza, Letícia Martins& Veloso, Roberto V.& Arantes, Vanessa Cristina& Kawashita, Nair H.…[et al.]. Nutritional Recovery with a Soybean Diet after Weaning Reduces Lipogenesis but Induces Inflammation in the Liver in Adult Rats Exposed to Protein Restriction during Intrauterine Life and Lactation. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1072550
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072550