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The Role of IL-1β in the Bone Loss during Rheumatic Diseases
Joint Authors
Carubbi, Francesco
Cipriani, Paola
Giacomelli, Roberto
Ruscitti, Piero
Liakouli, Vasiliki
Di Benedetto, Paola
Berardicurti, Onorina
Alesse, Edoardo
Zazzeroni, Francesca
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Several inflammatory diseases have been associated with increased bone resorption and fracture rates and different studies supported the relation between inflammatory cytokines and osteoclast activity.
The main factor required for osteoclast activation is the stimulation by receptor activator of nuclear factor kappa-B ligand (RANKL) expressed on osteoblasts.
In this context, interleukin- (IL-) 1β, one of the most powerful proinflammatory cytokines, is a strong stimulator of in vitro and in vivo bone resorption via upregulation of RANKL that stimulates the osteoclastogenesis.
The resulting effects lead to an imbalance in bone metabolism favouring bone resorption and osteoporosis.
In this paper, we review the available literature on the role of IL-1β in the pathogenesis of bone loss.
Furthermore, we analysed the role of IL-1β in bone resorption during rheumatic diseases and, when available, we reported the efficacy of anti-IL-1β therapy in this field.
American Psychological Association (APA)
Ruscitti, Piero& Cipriani, Paola& Carubbi, Francesco& Liakouli, Vasiliki& Zazzeroni, Francesca& Di Benedetto, Paola…[et al.]. 2015. The Role of IL-1β in the Bone Loss during Rheumatic Diseases. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072551
Modern Language Association (MLA)
Ruscitti, Piero…[et al.]. The Role of IL-1β in the Bone Loss during Rheumatic Diseases. Mediators of Inflammation No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1072551
American Medical Association (AMA)
Ruscitti, Piero& Cipriani, Paola& Carubbi, Francesco& Liakouli, Vasiliki& Zazzeroni, Francesca& Di Benedetto, Paola…[et al.]. The Role of IL-1β in the Bone Loss during Rheumatic Diseases. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072551
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072551