Effect of Weight-Reduction in Obese Mice Lacking Toll-Like Receptor 5 and C57BL6 Mice Fed a Low-Fat Diet
Joint Authors
Wu, Shao-Chun
Rau, Cheng-Shyuan
Lu, Tsu-Hsiang
Wu, Yi-Chan
Tzeng, Siou-Ling
Wu, Chia-Jung
Hsieh, Ching-Hua
Lin, Chia-Wei
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-23
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
This study aims to investigate the effect of feeding low-fat diet (LFD) to diet-induced obesity (DIO) mice lacking TLR5 (TLR5−/−), which have a tendency to develop glucose intolerance with increased adiposity, compared to that in C57BL/6 mice.
Results.
TLR5−/− and C57BL/6 male mice were divided into three subgroups: (1) control, mice were fed a standard AIN-76A (fat: 11.5 kcal%) diet for 12 weeks; (2) DIO, mice were fed a 58 kcal% high-fat diet (HFD) for 12 weeks; and (3) diet, mice were fed a HFD for 8 weeks to induce obesity and then switched to a 10.5 kcal% LFD for 4 weeks.
The glucose intolerance in DIO TLR5−/− mice was more significant than that in DIO C57BL/6 mice and was not attenuated by a switch to the LFD.
Weight-reduction with LFD had significantly decreased the epididymal fat mass in C57BL/6 mice but not in TLR5−/− mice.
In addition, the LFD-fed TLR5−/− mice showed significantly higher expression of ghrelin in the serum and resistin in the epididymal fat than that in C57BL/6 mice.
Conclusions.
This study demonstrated that TLR5 gene knockout impairs some effects of weight-reduction in DIO.
American Psychological Association (APA)
Wu, Shao-Chun& Rau, Cheng-Shyuan& Lu, Tsu-Hsiang& Tzeng, Siou-Ling& Wu, Yi-Chan& Wu, Chia-Jung…[et al.]. 2015. Effect of Weight-Reduction in Obese Mice Lacking Toll-Like Receptor 5 and C57BL6 Mice Fed a Low-Fat Diet. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1072612
Modern Language Association (MLA)
Wu, Shao-Chun…[et al.]. Effect of Weight-Reduction in Obese Mice Lacking Toll-Like Receptor 5 and C57BL6 Mice Fed a Low-Fat Diet. Mediators of Inflammation No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1072612
American Medical Association (AMA)
Wu, Shao-Chun& Rau, Cheng-Shyuan& Lu, Tsu-Hsiang& Tzeng, Siou-Ling& Wu, Yi-Chan& Wu, Chia-Jung…[et al.]. Effect of Weight-Reduction in Obese Mice Lacking Toll-Like Receptor 5 and C57BL6 Mice Fed a Low-Fat Diet. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1072612
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072612