Reactive Oxygen Species Donors Increase the Responsiveness of Dorsal Horn Neurons and Induce Mechanical Hyperalgesia in Rats
Joint Authors
Lee, Inhyung
Kim, Hee Young
Chun, Sang Woo
Kim, Hee Kee
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Our previous studies suggest that reactive oxygen species (ROS) scavengers have analgesic effect on neuropathic pain through spinal mechanisms in the rat.
The studies suggest that superoxide in spinal cord is one of important mediators of persistent pain.
To test the hypothesis that increase of superoxide-derived intermediates leads to central sensitization and pain, the effects of an intrathecal injection of chemical ROS donors releasing either OH∙, OCl-, or H2O2 were examined on pain behaviors.
Following treatment with t-BOOH (OH∙ donor), dorsal horn neuron responses to mechanical stimuli in normal rats and the changes of neuronal excitability were explored on substantia gelatinosa (SG) neurons using whole-cell patch clamping recordings.
Intrathecal administration of t-BOOH or NaOCl (OCl- donor), but not H2O2, significantly decreased mechanical thresholds of hind paws.
The responses of wide dynamic range neurons to mechanical stimuli increased after a local application of t-BOOH.
The t-BOOH increased the frequency and the amplitude of excitatory postsynaptic potentials, depolarized membrane potential in SG neurons, and increased the frequency of action potentials evoked by depolarizing current pulses.
These results suggest that elevated ROS, especially OH∙, in the spinal cord sensitized dorsal horn neurons and produced hyperalgesia in normal rats.
American Psychological Association (APA)
Kim, Hee Young& Lee, Inhyung& Chun, Sang Woo& Kim, Hee Kee. 2015. Reactive Oxygen Species Donors Increase the Responsiveness of Dorsal Horn Neurons and Induce Mechanical Hyperalgesia in Rats. Neural Plasticity،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075317
Modern Language Association (MLA)
Kim, Hee Young…[et al.]. Reactive Oxygen Species Donors Increase the Responsiveness of Dorsal Horn Neurons and Induce Mechanical Hyperalgesia in Rats. Neural Plasticity No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1075317
American Medical Association (AMA)
Kim, Hee Young& Lee, Inhyung& Chun, Sang Woo& Kim, Hee Kee. Reactive Oxygen Species Donors Increase the Responsiveness of Dorsal Horn Neurons and Induce Mechanical Hyperalgesia in Rats. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075317
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075317