Full Anatomical Recovery of the Dopaminergic System after a Complete Spinal Cord Injury in Lampreys
Joint Authors
Barreiro-Iglesias, Antón
Fernández-López, Blanca
Romaus-Sanjurjo, Daniel
Cornide-Petronio, María Eugenia
Gómez-Fernández, Sonia
Rodicio, María Celina
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Following a spinal injury, lampreys at first are paralyzed below the level of transection.
However, they recover locomotion after several weeks, and this is accompanied by the regeneration of descending axons from the brain and the production of new neurons in the spinal cord.
Here, we aimed to analyse the changes in the dopaminergic system of the sea lamprey after a complete spinal transection by studying the changes in dopaminergic cell numbers and dopaminergic innervation in the spinal cord.
Changes in the expression of the D2 receptor were also studied.
We report the full anatomical regeneration of the dopaminergic system after an initial decrease in the number of dopaminergic cells and fibres.
Numbers of dopaminergic cells were recovered rostrally and caudally to the site of injury.
Quantification of dopaminergic profiles revealed the full recovery of the dopaminergic innervation of the spinal cord rostral and caudal to the site of injury.
Interestingly, no changes in the expression of the D2 receptor were observed at time points in which a reduced dopaminergic innervation of the spinal cord was observed.
Our observations reveal that in lampreys a spinal cord injury is followed by the full anatomical recovery of the dopaminergic system.
American Psychological Association (APA)
Fernández-López, Blanca& Romaus-Sanjurjo, Daniel& Cornide-Petronio, María Eugenia& Gómez-Fernández, Sonia& Barreiro-Iglesias, Antón& Rodicio, María Celina. 2015. Full Anatomical Recovery of the Dopaminergic System after a Complete Spinal Cord Injury in Lampreys. Neural Plasticity،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075326
Modern Language Association (MLA)
Fernández-López, Blanca…[et al.]. Full Anatomical Recovery of the Dopaminergic System after a Complete Spinal Cord Injury in Lampreys. Neural Plasticity No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1075326
American Medical Association (AMA)
Fernández-López, Blanca& Romaus-Sanjurjo, Daniel& Cornide-Petronio, María Eugenia& Gómez-Fernández, Sonia& Barreiro-Iglesias, Antón& Rodicio, María Celina. Full Anatomical Recovery of the Dopaminergic System after a Complete Spinal Cord Injury in Lampreys. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075326
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075326