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A Neurologist’s Guide to TNF Biology and to the Principles behind the Therapeutic Removal of Excess TNF in Disease
Joint Authors
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Tumor necrosis factor (TNF) is an ancient and widespread cytokine required in small amounts for much physiological function.
Higher concentrations are central to innate immunity, but if unchecked this cytokine orchestrates much chronic and acute disease, both infectious and noninfectious.
While being a major proinflammatory cytokine, it also controls homeostasis and plasticity in physiological circumstances.
For the last decade or so these principles have been shown to apply to the central nervous system as well as the rest of the body.
Nevertheless, whereas this approach has been a major success in treating noncerebral disease, its investigation and potential widespread adoption in chronic neurological conditions has inexplicably stalled since the first open trial almost a decade ago.
While neuroscience is closely involved with this approach, clinical neurology appears to be reticent in engaging with what it offers patients.
Unfortunately, the basic biology of TNF and its relevance to disease is largely outside the traditions of neurology.
The purpose of this review is to facilitate lowering communication barriers between the traditional anatomically based medical specialties through recognition of shared disease mechanisms and thus advance the prospects of a large group of patients with neurodegenerative conditions for whom at present little can be done.
American Psychological Association (APA)
Clark, Ian A.& Vissel, Bryce. 2015. A Neurologist’s Guide to TNF Biology and to the Principles behind the Therapeutic Removal of Excess TNF in Disease. Neural Plasticity،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075327
Modern Language Association (MLA)
Clark, Ian A.& Vissel, Bryce. A Neurologist’s Guide to TNF Biology and to the Principles behind the Therapeutic Removal of Excess TNF in Disease. Neural Plasticity No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1075327
American Medical Association (AMA)
Clark, Ian A.& Vissel, Bryce. A Neurologist’s Guide to TNF Biology and to the Principles behind the Therapeutic Removal of Excess TNF in Disease. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075327
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075327