Lithium and Valproate Levels Do Not Correlate with Ketamine’s Antidepressant Efficacy in Treatment-Resistant Bipolar Depression
Joint Authors
Machado-Vieira, Rodrigo
Xu, Annie J.
Niciu, Mark J.
Lundin, Nancy B.
Luckenbaugh, David A.
Ionescu, Dawn F.
Richards, Erica M.
Vande Voort, Jennifer L.
Ballard, Elizabeth D.
Brutsche, Nancy E.
Zarate, Carlos A.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Ketamine and lithium both inhibit glycogen synthase kinase 3.
In addition, lithium and ketamine have synergistic antidepressant-like effects at individually subeffective doses in rodents.
We hypothesized that ketamine’s antidepressant effects would be improved by therapeutic doses of lithium versus valproate and that serum lithium levels would positively correlate with ketamine’s antidepressant efficacy.
Thirty-six patients with treatment-resistant bipolar depression maintained on therapeutic-dose lithium (n=23, 0.79 ± 0.15 mEq/L) or valproate (n=13, 79.6 ± 12.4 mg/mL) received 0.5 mg/kg ketamine infusion in a randomized, double-blind, placebo-controlled, crossover trial.
The primary depression outcome measure—the Montgomery-Åsberg Depression Rating Scale (MADRS)—was assessed before infusion and at numerous postinfusion time points.
Both lithium (F1,118 = 152.08, p<0.001, and d=2.27) and valproate (F1,128 = 20.12, p<0.001, and d=0.79) significantly improved depressive symptoms, but no statistically significant difference was observed between mood stabilizer groups (F1,28 = 2.51, p=0.12, and d=0.60).
Serum lithium and valproate levels did not correlate with ketamine’s antidepressant efficacy.
Although the study was potentially underpowered, our results suggest that lithium may not potentiate ketamine’s antidepressant efficacy in treatment-resistant bipolar depression.
American Psychological Association (APA)
Xu, Annie J.& Niciu, Mark J.& Lundin, Nancy B.& Luckenbaugh, David A.& Ionescu, Dawn F.& Richards, Erica M.…[et al.]. 2015. Lithium and Valproate Levels Do Not Correlate with Ketamine’s Antidepressant Efficacy in Treatment-Resistant Bipolar Depression. Neural Plasticity،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1075420
Modern Language Association (MLA)
Xu, Annie J.…[et al.]. Lithium and Valproate Levels Do Not Correlate with Ketamine’s Antidepressant Efficacy in Treatment-Resistant Bipolar Depression. Neural Plasticity No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1075420
American Medical Association (AMA)
Xu, Annie J.& Niciu, Mark J.& Lundin, Nancy B.& Luckenbaugh, David A.& Ionescu, Dawn F.& Richards, Erica M.…[et al.]. Lithium and Valproate Levels Do Not Correlate with Ketamine’s Antidepressant Efficacy in Treatment-Resistant Bipolar Depression. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1075420
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075420