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Is Parkinson’s Disease Truly a Prion-Like Disorder? An Appraisal of Current Evidence
Joint Authors
Chauhan, Aneesha
Jeans, Alexander F.
Source
Neurology Research International
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Parkinson’s disease (PD) is the world’s second most common neurodegenerative disease and most common movement disorder.
Characterised by a loss of dopaminergic neurons and the development of intraneuronal inclusions known as Lewy bodies, it has classically been thought of as a cell-autonomous disease.
However, in 2008, two groups reported the startling observation of Lewy bodies within embryonic neuronal grafts transplanted into PD patients little more than a decade previously, suggesting that PD pathology can be propagated to neighbouring cells and calling basic assumptions of our understanding of the disease into question.
Subsequent research has largely served to confirm this interpretation, pointing towards a prion-like intercellular transfer of misfolded α-synuclein, the main component of Lewy bodies, as central to PD.
This shift in thinking offers a revolutionary approach to PD treatment, potentially enabling a transition from purely symptomatic therapy to direct targeting of the pathology that drives disease progression.
In this short review, we appraise current experimental support for PD as a prion-like disease, whilst highlighting areas of controversy or inconsistency which must be resolved.
We also offer a brief discussion of the therapeutic implications of these discoveries.
American Psychological Association (APA)
Chauhan, Aneesha& Jeans, Alexander F.. 2015. Is Parkinson’s Disease Truly a Prion-Like Disorder? An Appraisal of Current Evidence. Neurology Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075440
Modern Language Association (MLA)
Chauhan, Aneesha& Jeans, Alexander F.. Is Parkinson’s Disease Truly a Prion-Like Disorder? An Appraisal of Current Evidence. Neurology Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1075440
American Medical Association (AMA)
Chauhan, Aneesha& Jeans, Alexander F.. Is Parkinson’s Disease Truly a Prion-Like Disorder? An Appraisal of Current Evidence. Neurology Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075440
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075440