A Reappraisal of Women’s Health Initiative Estrogen-Alone Trial: Long-Term Outcomes in Women 50–59 Years of Age
Author
Source
Obstetrics and Gynecology International
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The Women’s Health Initiative (WHI) Estrogen-Alone Trial randomized postmenopausal women, 50 to 79 years of age, with prior hysterectomy, to conjugated equine estrogens (CEE) or placebo with a 5.9-year median duration of CEE use.
In 2013, the WHI published outcomes for additional extended follow-up.
Reported here for the first time is an analysis of the number needed to treat with CEE rather than placebo for younger women (50–59 years) to prevent an adverse long-term outcome.
For every 76 women randomized to CEE at 50–59 years, one less myocardial infarction occurred during the 13-year cumulative long-term follow-up.
For every 37 women randomized to CEE at 50–59 years, one less woman experienced a global index endpoint (including coronary heart disease, invasive breast cancer, stroke, pulmonary embolism, colorectal cancer, hip fracture, and death) during the 13-year follow-up.
Younger women (50–59 years), compared to older women, had more favorable cumulative long-term outcomes for MI and global index.
Though a subgroup analysis is not an adequate basis for making primary prevention guideline recommendations, the WHI Estrogen-Alone Trial outcomes strongly suggest that a similar course of estrogen initiated at 50–59 years in postmenopausal women with prior hysterectomy results in significant long-term health benefit.
American Psychological Association (APA)
Roehm, Eric. 2015. A Reappraisal of Women’s Health Initiative Estrogen-Alone Trial: Long-Term Outcomes in Women 50–59 Years of Age. Obstetrics and Gynecology International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075511
Modern Language Association (MLA)
Roehm, Eric. A Reappraisal of Women’s Health Initiative Estrogen-Alone Trial: Long-Term Outcomes in Women 50–59 Years of Age. Obstetrics and Gynecology International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1075511
American Medical Association (AMA)
Roehm, Eric. A Reappraisal of Women’s Health Initiative Estrogen-Alone Trial: Long-Term Outcomes in Women 50–59 Years of Age. Obstetrics and Gynecology International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075511
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075511