Failure Rate of Single Dose Methotrexate in Managment of Ectopic Pregnancy
Joint Authors
Sendy, Feras
AlShehri, Eman
AlAjmi, Amani
Bamanie, Elham
Appani, Surekha
Shams, Taghreed
Source
Obstetrics and Gynecology International
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-12
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
One of the treatment modalities for ectopic pregnancy is methotrexate.
The purpose of this study is to identify the failure rate of methotrexate in treating patients with ectopic pregnancy as well as the risk factors leading to treatment failure.
Methods.
A retrospective chart review of 225 patients who received methotrexate as a primary management option for ectopic pregnancy.
Failure of single dose of methotrexate was defined as drop of BHCG level less than or equal to 14% in the seventh day after administration of methotrexate.
Results.
225 patients had methotrexate.
Most of the patients (151 (67%)) received methotrexate based on the following formula: f 50 mg X body surface area.
Single dose of methotrexate was successful in 72% (162/225) of the patients.
28% (63/225) were labeled as failure of single dose of methotrexate because of suboptimal drop in BhCG.
63% (40/63) of failure received a second dose of methotrexate, and 37% (23/63) underwent surgical treatment.
Among patient who received initial dose of methotrexate, 71% had moderate or severe pain, and 58% had ectopic mass size of more than 4 cm on ultrasound.
Conclusion.
Liberal use of medical treatment of ectopic pregnancy results in 71% success rate.
American Psychological Association (APA)
Sendy, Feras& AlShehri, Eman& AlAjmi, Amani& Bamanie, Elham& Appani, Surekha& Shams, Taghreed. 2015. Failure Rate of Single Dose Methotrexate in Managment of Ectopic Pregnancy. Obstetrics and Gynecology International،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1075516
Modern Language Association (MLA)
Sendy, Feras…[et al.]. Failure Rate of Single Dose Methotrexate in Managment of Ectopic Pregnancy. Obstetrics and Gynecology International No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1075516
American Medical Association (AMA)
Sendy, Feras& AlShehri, Eman& AlAjmi, Amani& Bamanie, Elham& Appani, Surekha& Shams, Taghreed. Failure Rate of Single Dose Methotrexate in Managment of Ectopic Pregnancy. Obstetrics and Gynecology International. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1075516
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075516