Protective Mechanisms of Flavonoids in Parkinson’s Disease
Joint Authors
Radhakrishnan, Ammu
Magalingam, Kasthuri Bai
Haleagrahara, Nagaraja
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-20
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Parkinson’s disease is a chronic, debilitating neurodegenerative movement disorder characterized by progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta region in human midbrain.
To date, oxidative stress is the well accepted concept in the etiology and progression of Parkinson’s disease.
Hence, the therapeutic agent is targeted against suppressing and alleviating the oxidative stress-induced cellular damage.
Within the past decades, an explosion of research discoveries has reported on the protective mechanisms of flavonoids, which are plant-based polyphenols, in the treatment of neurodegenerative disease using both in vitro and in vivo models.
In this paper, we have reviewed the literature on the neuroprotective mechanisms of flavonoids in protecting the dopaminergic neurons hence reducing the symptoms of this movement disorder.
The mechanism reviewed includes effect of flavonoids in activation of endogenous antioxidant enzymes, suppressing the lipid peroxidation, inhibition of inflammatory mediators, flavonoids as a mitochondrial target therapy, and modulation of gene expression in neuronal cells.
American Psychological Association (APA)
Magalingam, Kasthuri Bai& Radhakrishnan, Ammu& Haleagrahara, Nagaraja. 2015. Protective Mechanisms of Flavonoids in Parkinson’s Disease. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1075587
Modern Language Association (MLA)
Magalingam, Kasthuri Bai…[et al.]. Protective Mechanisms of Flavonoids in Parkinson’s Disease. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1075587
American Medical Association (AMA)
Magalingam, Kasthuri Bai& Radhakrishnan, Ammu& Haleagrahara, Nagaraja. Protective Mechanisms of Flavonoids in Parkinson’s Disease. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1075587
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075587