Novel Antioxidant Tripeptide “ACQ” Can Prevent UV-Induced Cell Death and Preserve the Number of Epidermal Stem Cells
Joint Authors
Choi, Hye-Ryung
Na, Jung-Im
Nam, Kyung-Mi
Lee, Hyun-Sun
Shin, Jung-Won
Park, Kyoung-Chan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-25
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
We found that tripeptide “ACQ: alanine-cysteine-glutamine” has significant DPPH scavenging activity compared to that of glutathione.
Antioxidant effects of ACQ were tested in in vitro and in vivo models.
When treated with H2O2, mock treated fibroblasts and keratinocytes showed strong staining by H2DCFA.
But, ACQ showed good protective effects against hydrogen peroxide treatment.
When mice were fed for 2 or 4 weeks, similar protective effects were observed.
In the control group, epidermis was severely damaged by UV irradiation and apoptotic keratinocytes were observed.
There were also numerous TUNEL positive cells.
But in the ACQ group, epidermis became thicker and there was no sign of severe damage.
Interestingly, the number of p63 cells was also higher in ACQ fed mice.
To confirm the stem cell rescuing effects of ACQ, three-dimensional skin samples were constructed.
Results showed that ACQ increased the expression of integrin α6 and the number of p63 positive cells.
These findings showed that ACQ has good antioxidant activity and may increase stem cell activities by the regulation of integrin α6.
American Psychological Association (APA)
Choi, Hye-Ryung& Shin, Jung-Won& Na, Jung-Im& Nam, Kyung-Mi& Lee, Hyun-Sun& Park, Kyoung-Chan. 2015. Novel Antioxidant Tripeptide “ACQ” Can Prevent UV-Induced Cell Death and Preserve the Number of Epidermal Stem Cells. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075602
Modern Language Association (MLA)
Choi, Hye-Ryung…[et al.]. Novel Antioxidant Tripeptide “ACQ” Can Prevent UV-Induced Cell Death and Preserve the Number of Epidermal Stem Cells. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1075602
American Medical Association (AMA)
Choi, Hye-Ryung& Shin, Jung-Won& Na, Jung-Im& Nam, Kyung-Mi& Lee, Hyun-Sun& Park, Kyoung-Chan. Novel Antioxidant Tripeptide “ACQ” Can Prevent UV-Induced Cell Death and Preserve the Number of Epidermal Stem Cells. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075602
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075602