Mitochondria-Targeted Protective Compounds in Parkinson’s and Alzheimer’s Diseases
Joint Authors
Fernández-Moriano, Carlos
González-Burgos, Elena
Gómez-Serranillos, M. Pilar
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-30, 30 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-29
Country of Publication
Egypt
No. of Pages
30
Main Subjects
Abstract EN
Mitochondria are cytoplasmic organelles that regulate both metabolic and apoptotic signaling pathways; their most highlighted functions include cellular energy generation in the form of adenosine triphosphate (ATP), regulation of cellular calcium homeostasis, balance between ROS production and detoxification, mediation of apoptosis cell death, and synthesis and metabolism of various key molecules.
Consistent evidence suggests that mitochondrial failure is associated with early events in the pathogenesis of ageing-related neurodegenerative disorders including Parkinson’s disease and Alzheimer’s disease.
Mitochondria-targeted protective compounds that prevent or minimize mitochondrial dysfunction constitute potential therapeutic strategies in the prevention and treatment of these central nervous system diseases.
This paper provides an overview of the involvement of mitochondrial dysfunction in Parkinson’s and Alzheimer’s diseases, with particular attention to in vitro and in vivo studies on promising endogenous and exogenous mitochondria-targeted protective compounds.
American Psychological Association (APA)
Fernández-Moriano, Carlos& González-Burgos, Elena& Gómez-Serranillos, M. Pilar. 2015. Mitochondria-Targeted Protective Compounds in Parkinson’s and Alzheimer’s Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-30.
https://search.emarefa.net/detail/BIM-1075642
Modern Language Association (MLA)
Fernández-Moriano, Carlos…[et al.]. Mitochondria-Targeted Protective Compounds in Parkinson’s and Alzheimer’s Diseases. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-30.
https://search.emarefa.net/detail/BIM-1075642
American Medical Association (AMA)
Fernández-Moriano, Carlos& González-Burgos, Elena& Gómez-Serranillos, M. Pilar. Mitochondria-Targeted Protective Compounds in Parkinson’s and Alzheimer’s Diseases. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-30.
https://search.emarefa.net/detail/BIM-1075642
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075642