The Role of Oxygen Sensors, Hydroxylases, and HIF in Cardiac Function and Disease
Joint Authors
Pi, Xinchun
Townley-Tilson, W. H. Davin
Xie, Liang
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Ischemic heart disease is the leading cause of death worldwide.
Oxygen-sensing proteins are critical components of the physiological response to hypoxia and reperfusion injury, but the role of oxygen and oxygen-mediated effects is complex in that they can be cardioprotective or deleterious to the cardiac tissue.
Over 200 oxygen-sensing proteins mediate the effects of oxygen tension and use oxygen as a substrate for posttranslational modification of other proteins.
Hydroxylases are an essential component of these oxygen-sensing proteins.
While a major role of hydroxylases is regulating the transcription factor HIF, we investigate the increasing scope of hydroxylase substrates.
This review discusses the importance of oxygen-mediated effects in the heart as well as how the field of oxygen-sensing proteins is expanding, providing a more complete picture into how these enzymes play a multifaceted role in cardiac function and disease.
We also review how oxygen-sensing proteins and hydroxylase function could prove to be invaluable in drug design and therapeutic targets for heart disease.
American Psychological Association (APA)
Townley-Tilson, W. H. Davin& Pi, Xinchun& Xie, Liang. 2015. The Role of Oxygen Sensors, Hydroxylases, and HIF in Cardiac Function and Disease. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075733
Modern Language Association (MLA)
Townley-Tilson, W. H. Davin…[et al.]. The Role of Oxygen Sensors, Hydroxylases, and HIF in Cardiac Function and Disease. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1075733
American Medical Association (AMA)
Townley-Tilson, W. H. Davin& Pi, Xinchun& Xie, Liang. The Role of Oxygen Sensors, Hydroxylases, and HIF in Cardiac Function and Disease. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075733
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075733