Dietary Tocotrienolγ-Cyclodextrin Complex Increases Mitochondrial Membrane Potential and ATP Concentrations in the Brains of Aged Mice
Joint Authors
Schloesser, Anke
Esatbeyoglu, Tuba
Piegholdt, Stefanie
Dose, Janina
Ikuta, Naoko
Okamoto, Hinako
Ishida, Yoshiyuki
Terao, Keiji
Matsugo, Seiichi
Rimbach, Gerald
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Brain aging is accompanied by a decrease in mitochondrial function.
In vitro studies suggest that tocotrienols, including γ- and δ-tocotrienol (T3), may exhibit neuroprotective properties.
However, little is known about the effect of dietary T3 on mitochondrial function in vivo.
In this study, we monitored the effect of a dietary T3/γ-cyclodextrin complex (T3CD) on mitochondrial membrane potential and ATP levels in the brain of 21-month-old mice.
Mice were fed either a control diet or a diet enriched with T3CD providing 100 mg T3 per kg diet for 6 months.
Dietary T3CD significantly increased mitochondrial membrane potential and ATP levels compared to those of controls.
The increase in MMP and ATP due to dietary T3CD was accompanied by an increase in the protein levels of the mitochondrial transcription factor A (TFAM).
Furthermore, dietary T3CD slightly increased the mRNA levels of superoxide dismutase, γ-glutamyl cysteinyl synthetase, and heme oxygenase 1 in the brain.
Overall, the present data suggest that T3CD increases TFAM, mitochondrial membrane potential, and ATP synthesis in the brains of aged mice.
American Psychological Association (APA)
Schloesser, Anke& Esatbeyoglu, Tuba& Piegholdt, Stefanie& Dose, Janina& Ikuta, Naoko& Okamoto, Hinako…[et al.]. 2015. Dietary Tocotrienolγ-Cyclodextrin Complex Increases Mitochondrial Membrane Potential and ATP Concentrations in the Brains of Aged Mice. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075773
Modern Language Association (MLA)
Schloesser, Anke…[et al.]. Dietary Tocotrienolγ-Cyclodextrin Complex Increases Mitochondrial Membrane Potential and ATP Concentrations in the Brains of Aged Mice. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1075773
American Medical Association (AMA)
Schloesser, Anke& Esatbeyoglu, Tuba& Piegholdt, Stefanie& Dose, Janina& Ikuta, Naoko& Okamoto, Hinako…[et al.]. Dietary Tocotrienolγ-Cyclodextrin Complex Increases Mitochondrial Membrane Potential and ATP Concentrations in the Brains of Aged Mice. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075773
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075773