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Alzheimer’s Pathogenesis and Its Link to the Mitochondrion
Joint Authors
Ienco, Elena Caldarazzo
Simoncini, C.
Orsucci, D.
Mancuso, Michelangelo
Siciliano, Gabriele
Bonuccelli, Ubaldo
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Alzheimer’s disease (AD) is the most common form of dementia in the elderly.
This neurodegenerative disorder is clinically characterized by impairment of cognitive functions and changes in behaviour and personality.
The pathogenesis of AD is still unclear.
Recent evidence supports some role of mitochondria dysfunction and oxidative stress in the development of the neurodegenerative process.
In this review, we discuss the role of mitochondrial dysfunction in AD, focusing on the mechanisms that lead to mitochondrial impairment, oxidative stress, and neurodegeneration, a “vicious circle” that ends in dementia.
American Psychological Association (APA)
Simoncini, C.& Orsucci, D.& Ienco, Elena Caldarazzo& Siciliano, Gabriele& Bonuccelli, Ubaldo& Mancuso, Michelangelo. 2015. Alzheimer’s Pathogenesis and Its Link to the Mitochondrion. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075778
Modern Language Association (MLA)
Simoncini, C.…[et al.]. Alzheimer’s Pathogenesis and Its Link to the Mitochondrion. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1075778
American Medical Association (AMA)
Simoncini, C.& Orsucci, D.& Ienco, Elena Caldarazzo& Siciliano, Gabriele& Bonuccelli, Ubaldo& Mancuso, Michelangelo. Alzheimer’s Pathogenesis and Its Link to the Mitochondrion. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075778
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075778