Flaxseed Oil Containing α-Linolenic Acid Ester of Plant Sterol Improved Atherosclerosis in ApoE Deficient Mice
Joint Authors
Liu, Liegang
Han, Hao
Yan, Peipei
Chen, Li
Luo, Cheng
Gao, Hui
Deng, Qianchun
Zheng, Mingming
Shi, Yong
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-09
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Plant sterols (PS) have potential preventive function in atherosclerosis due to their cholesterol-lowering ability.
Dietary α-linolenic acid in flaxseed oil is associated with a reduction in cardiovascular events through its hypolipidemic and anti-inflammation properties.
This study was designed to evaluate the effects of flaxseed oil containing α-linolenic acid ester of PS (ALA-PS) on atherosclerosis and investigate the underlying mechanisms.
C57BL/6 mice were administered a regular diet and apoE knockout (apoE-KO) mice were given a high fat diet alone or supplemented with 5% flaxseed oil with or without 3.3% ALA-PS for 18 weeks.
Results demonstrated that flaxseed oil containing ALA-PS was synergistically interaction in ameliorating atherosclerosis as well as optimizing overall lipid levels, inhibiting inflammation and reducing oxidative stress.
These data were associated with the modification effects on expression levels of genes involved in lipid metabolism (PPARα, HMGCR, and SREBPs), inflammation (IL-6, TNF, MCP-1, and VCAM-1), and oxidative stress (NADPH oxidase).
American Psychological Association (APA)
Han, Hao& Yan, Peipei& Chen, Li& Luo, Cheng& Gao, Hui& Deng, Qianchun…[et al.]. 2015. Flaxseed Oil Containing α-Linolenic Acid Ester of Plant Sterol Improved Atherosclerosis in ApoE Deficient Mice. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1075820
Modern Language Association (MLA)
Han, Hao…[et al.]. Flaxseed Oil Containing α-Linolenic Acid Ester of Plant Sterol Improved Atherosclerosis in ApoE Deficient Mice. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1075820
American Medical Association (AMA)
Han, Hao& Yan, Peipei& Chen, Li& Luo, Cheng& Gao, Hui& Deng, Qianchun…[et al.]. Flaxseed Oil Containing α-Linolenic Acid Ester of Plant Sterol Improved Atherosclerosis in ApoE Deficient Mice. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1075820
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075820