Effect of GBA Mutations on Phenotype of Parkinson’s Disease: A Study on Chinese Population and a Meta-Analysis
Joint Authors
Zhang, Yuan
Sun, Qi-ying
Zhao, Yu-wen
Shu, Li
Guo, Ji-feng
Xu, Qian
Yan, Xin-xiang
Tang, Bei-sha
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
GBA has been identified as a genetic risk factor for PD.
Whether the clinical manifestations of PD patients with or without GBA mutations are different has still not reached a consensus.
We firstly detected the GBA mutation L444P in 1147 Chinese PD patients and simultaneously evaluated their corresponding clinical data.
Then we compared the phenotypes between 646 PD patients with GBA mutations and 10344 PD patients without GBA mutations worldwide through meta-analysis.
Through the method of meta-analysis, there was significant difference in age at onset (MD = −3.10 [95% CI: −4.88, −1.32]), bradykinesia as an initial symptom (OR = 1.49 [95% CI: 1.15, 1.94]), having family history (OR = 1.50 [95% CI: 1.18, 1.91]), and dementia (OR = 3.21 [95% CI: 1.97, 5.24]) during the comparison between PD patients with and without GBA mutations.
While, in the aspect of tremor as an initial symptom (OR = 0.81 [95% CI: 0.64, 1.03]), the severity of motor symptoms such as H-Y (MD = 0.06 [95% CI: −0.06, 0.17]) and UPDRS-III (MD = 1.61 [95% CI: −0.65, 3.87]) and having dyskinesia (OR = 1.60 [95% CI: 0.90, 2.84]) during the comparison between the two groups revealed no statistical differences.
Our results suggested that the phenotypes of PD patients with GBA mutations are different from GBA noncarriers.
American Psychological Association (APA)
Zhang, Yuan& Sun, Qi-ying& Zhao, Yu-wen& Shu, Li& Guo, Ji-feng& Xu, Qian…[et al.]. 2015. Effect of GBA Mutations on Phenotype of Parkinson’s Disease: A Study on Chinese Population and a Meta-Analysis. Parkinson’s Disease،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075923
Modern Language Association (MLA)
Zhang, Yuan…[et al.]. Effect of GBA Mutations on Phenotype of Parkinson’s Disease: A Study on Chinese Population and a Meta-Analysis. Parkinson’s Disease No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1075923
American Medical Association (AMA)
Zhang, Yuan& Sun, Qi-ying& Zhao, Yu-wen& Shu, Li& Guo, Ji-feng& Xu, Qian…[et al.]. Effect of GBA Mutations on Phenotype of Parkinson’s Disease: A Study on Chinese Population and a Meta-Analysis. Parkinson’s Disease. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075923
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075923