Association of a BACE1 Gene Polymorphism with Parkinson’s Disease in a Norwegian Population
Joint Authors
Lange, Johannes
Lunde, Kristin Aaser
Sletten, Camilla
Møller, Simon Geir
Tysnes, Ole-Bjørn
Alves, Guido
Larsen, Jan Petter
Maple-Grødem, Jodi
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-14
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Parkinson’s disease (PD) and Alzheimer’s disease (AD) share pathological features, including amyloid-beta pathology.
Amyloid-beta peptide is generated by sequential proteolysis of amyloid precursor protein (APP), and genetic variations in the processing pathway genes have been found to increase the risk of AD; however, the contribution in PD is unknown.
Methods.
The aim of this study was to investigate whether candidate polymorphisms in five genes (ADAM10, BACE1, BACE2, PSEN2, and CLU) involved in the APP processing pathway affect PD risk in a population-based cohort of patients with incident PD and control subjects from the Norwegian ParkWest study.
Results.
We found an association of rs638405 in BACE1 with increased risk of PD, thus providing a novel link, at the genetic level, between amyloid-beta pathology and PD.
American Psychological Association (APA)
Lange, Johannes& Lunde, Kristin Aaser& Sletten, Camilla& Møller, Simon Geir& Tysnes, Ole-Bjørn& Alves, Guido…[et al.]. 2015. Association of a BACE1 Gene Polymorphism with Parkinson’s Disease in a Norwegian Population. Parkinson’s Disease،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1075934
Modern Language Association (MLA)
Lange, Johannes…[et al.]. Association of a BACE1 Gene Polymorphism with Parkinson’s Disease in a Norwegian Population. Parkinson’s Disease No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1075934
American Medical Association (AMA)
Lange, Johannes& Lunde, Kristin Aaser& Sletten, Camilla& Møller, Simon Geir& Tysnes, Ole-Bjørn& Alves, Guido…[et al.]. Association of a BACE1 Gene Polymorphism with Parkinson’s Disease in a Norwegian Population. Parkinson’s Disease. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1075934
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075934