Treatment with PPARα Agonist Clofibrate Inhibits the Transcription and Activation of SREBPs and Reduces Triglyceride and Cholesterol Levels in Liver of Broiler Chickens
Joint Authors
Zhang, Lijun
Li, Chunyan
Wang, Fang
Zhou, Shenghua
Shangguan, Mingjun
Xue, Lina
Zhang, Bianying
Ding, Fuxiang
Hui, Dequan
Liang, Aihua
He, Dongchang
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
PPARα agonist clofibrate reduces cholesterol and fatty acid concentrations in rodent liver by an inhibition of SREBP-dependent gene expression.
In present study we investigated the regulation mechanisms of the triglyceride- and cholesterol-lowering effect of the PPARα agonist clofibrate in broiler chickens.
We observed that PPARα agonist clofibrate decreases the mRNA and protein levels of LXRα and the mRNA and both precursor and nuclear protein levels of SREBP1 and SREBP2 as well as the mRNA levels of the SREBP1 (FASN and GPAM) and SREBP2 (HMGCR and LDLR) target genes in the liver of treated broiler chickens compared to control group, whereas the mRNA level of INSIG2, which inhibits SREBP activation, was increased in the liver of treated broiler chickens compared to control group.
Taken together, the effects of PPARα agonist clofibrate on lipid metabolism in liver of broiler chickens involve inhibiting transcription and activation of SREBPs and SREBP-dependent lipogenic and cholesterologenic gene expression, thereby resulting in a reduction of the triglyceride and cholesterol levels in liver of broiler chickens.
American Psychological Association (APA)
Zhang, Lijun& Li, Chunyan& Wang, Fang& Zhou, Shenghua& Shangguan, Mingjun& Xue, Lina…[et al.]. 2015. Treatment with PPARα Agonist Clofibrate Inhibits the Transcription and Activation of SREBPs and Reduces Triglyceride and Cholesterol Levels in Liver of Broiler Chickens. PPAR Research،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075958
Modern Language Association (MLA)
Zhang, Lijun…[et al.]. Treatment with PPARα Agonist Clofibrate Inhibits the Transcription and Activation of SREBPs and Reduces Triglyceride and Cholesterol Levels in Liver of Broiler Chickens. PPAR Research No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1075958
American Medical Association (AMA)
Zhang, Lijun& Li, Chunyan& Wang, Fang& Zhou, Shenghua& Shangguan, Mingjun& Xue, Lina…[et al.]. Treatment with PPARα Agonist Clofibrate Inhibits the Transcription and Activation of SREBPs and Reduces Triglyceride and Cholesterol Levels in Liver of Broiler Chickens. PPAR Research. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075958
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075958