Bone Marrow-Derived, Neural-Like Cells Have the Characteristics of Neurons to Protect the Peripheral Nerve in Microenvironment
Joint Authors
Guo, Shi-lei
Zhang, Zhi-ying
Xu, Yan
Zhi, Yun-xia
Han, Chang-jie
Zhou, Yu-hao
Liu, Fang
Lin, Hai-yan
Zhang, Chuan-sen
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-15
Country of Publication
Egypt
No. of Pages
9
Abstract EN
Effective repair of peripheral nerve defects is difficult because of the slow growth of new axonal growth.
We propose that “neural-like cells” may be useful for the protection of peripheral nerve destructions.
Such cells should prolong the time for the disintegration of spinal nerves, reduce lesions, and improve recovery.
But the mechanism of neural-like cells in the peripheral nerve is still unclear.
In this study, bone marrow-derived neural-like cells were used as seed cells.
The cells were injected into the distal end of severed rabbit peripheral nerves that were no longer integrated with the central nervous system.
Electromyography (EMG), immunohistochemistry, and transmission electron microscopy (TEM) were employed to analyze the development of the cells in the peripheral nerve environment.
The CMAP amplitude appeared during the 5th week following surgery, at which time morphological characteristics of myelinated nerve fiber formation were observed.
Bone marrow-derived neural-like cells could protect the disintegration and destruction of the injured peripheral nerve.
American Psychological Association (APA)
Guo, Shi-lei& Zhang, Zhi-ying& Xu, Yan& Zhi, Yun-xia& Han, Chang-jie& Zhou, Yu-hao…[et al.]. 2015. Bone Marrow-Derived, Neural-Like Cells Have the Characteristics of Neurons to Protect the Peripheral Nerve in Microenvironment. Stem Cells International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1076388
Modern Language Association (MLA)
Guo, Shi-lei…[et al.]. Bone Marrow-Derived, Neural-Like Cells Have the Characteristics of Neurons to Protect the Peripheral Nerve in Microenvironment. Stem Cells International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1076388
American Medical Association (AMA)
Guo, Shi-lei& Zhang, Zhi-ying& Xu, Yan& Zhi, Yun-xia& Han, Chang-jie& Zhou, Yu-hao…[et al.]. Bone Marrow-Derived, Neural-Like Cells Have the Characteristics of Neurons to Protect the Peripheral Nerve in Microenvironment. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1076388
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076388