Development and Evaluation of Nanoemulsifying Preconcentrate of Curcumin for Colon Delivery
Joint Authors
Wadhwa, Jyoti
Asthana, Abhay
Shilkari Asthana, Gyati
Singh, Ranjit
Chopra, Arun Kumar
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-11
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
The present study aimed to develop and optimize a nanoemulsifying preconcentrate formulation of curcumin with good emulsification ability and optimal globule size, for controlled targeting in colon.
Content of formulation variables, namely, X1 (Peceol), X2 (Cremophor-EL), and X3 (Transcutol HP), were optimized by Box-Behnken design of experiments for its impact on mean globule size (Y1), emulsification time (Y2), and time required for drug release (85%) in phosphate buffer (pH 7.2), t85% (Y3).
Transmission electron micrographs confirmed that there is no coalescence among globules, with size range concordant with the globule size analysis by dynamic light scattering technique (100 nm).
3D plots indicated that concentration of formulation ingredients significantly influences the formulation properties (globule size, emulsification time, and drug release).
In vitro release profile (in phosphate buffer; pH 7.2) represents the fact that more than 50% of the drug was released within initial 15 min whereas in vivo release showed limited systemic absorption (Cmax 200 ng/mL) of curcumin.
Stability study ensures the protection of drug in alkaline media which may further confirm the localised delivery of drug to colonic region.
Study demonstrated that the nanoemulsifying preconcentrate can be a promising system for the colon specific delivery of curcumin to treat local pathologies.
American Psychological Association (APA)
Wadhwa, Jyoti& Asthana, Abhay& Shilkari Asthana, Gyati& Chopra, Arun Kumar& Singh, Ranjit. 2015. Development and Evaluation of Nanoemulsifying Preconcentrate of Curcumin for Colon Delivery. The Scientific World Journal،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1078881
Modern Language Association (MLA)
Wadhwa, Jyoti…[et al.]. Development and Evaluation of Nanoemulsifying Preconcentrate of Curcumin for Colon Delivery. The Scientific World Journal No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1078881
American Medical Association (AMA)
Wadhwa, Jyoti& Asthana, Abhay& Shilkari Asthana, Gyati& Chopra, Arun Kumar& Singh, Ranjit. Development and Evaluation of Nanoemulsifying Preconcentrate of Curcumin for Colon Delivery. The Scientific World Journal. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1078881
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1078881