Mathematical Modeling of Uniaxial Mechanical Properties of Collagen Gel Scaffolds for Vascular Tissue Engineering
Joint Authors
Irastorza, Ramiro M.
Drouin, Bernard
Blangino, Eugenia
Mantovani, Diego
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Small diameter tissue-engineered arteries improve their mechanical and functional properties when they are mechanically stimulated.
Applying a suitable stress and/or strain with or without a cycle to the scaffolds and cells during the culturing process resides in our ability to generate a suitable mechanical model.
Collagen gel is one of the most used scaffolds in vascular tissue engineering, mainly because it is the principal constituent of the extracellular matrix for vascular cells in human.
The mechanical modeling of such a material is not a trivial task, mainly for its viscoelastic nature.
Computational and experimental methods for developing a suitable model for collagen gels are of primary importance for the field.
In this research, we focused on mechanical properties of collagen gels under unconfined compression.
First, mechanical viscoelastic models are discussed and framed in the control system theory.
Second, models are fitted using system identification.
Several models are evaluated and two nonlinear models are proposed: Mooney-Rivlin inspired and Hammerstein models.
The results suggest that Mooney-Rivlin and Hammerstein models succeed in describing the mechanical behavior of collagen gels for cyclic tests on scaffolds (with best fitting parameters 58.3% and 75.8%, resp.).
When Akaike criterion is used, the best is the Mooney-Rivlin inspired model.
American Psychological Association (APA)
Irastorza, Ramiro M.& Drouin, Bernard& Blangino, Eugenia& Mantovani, Diego. 2015. Mathematical Modeling of Uniaxial Mechanical Properties of Collagen Gel Scaffolds for Vascular Tissue Engineering. The Scientific World Journal،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1079240
Modern Language Association (MLA)
Irastorza, Ramiro M.…[et al.]. Mathematical Modeling of Uniaxial Mechanical Properties of Collagen Gel Scaffolds for Vascular Tissue Engineering. The Scientific World Journal No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1079240
American Medical Association (AMA)
Irastorza, Ramiro M.& Drouin, Bernard& Blangino, Eugenia& Mantovani, Diego. Mathematical Modeling of Uniaxial Mechanical Properties of Collagen Gel Scaffolds for Vascular Tissue Engineering. The Scientific World Journal. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1079240
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1079240