The effect of some levels of fennel seeds against tramadol toxicity induced oxidative stress in rats

Abstract EN

The main objective of this study was to investigate the effectof fennel (Foeniculum Vulgare) seeds on serum parameters including kidney functions, liver enzymes, lipid profiles, malondialdehyde, superoxide dismutase (SOD), acetycholinesterase activities, total antioxidants and blood hemoglobin for Tramadol toxicity induced in rats.

The experiment was carried out using thirty male albino rats weighing 145±5g.

After the acclimatization period, rats were divided randomly into two main groups, the first main group (n= 6 rats) fed on the basal diet only as a negative control (normal group).

The second main group (n= 24 rats) were oral with tramadol hydrochloride at dose of (200 mg/kg bw.

) to induce tramadol toxicity.

The second main group (oral with tramadol) divided into 4 subgroups (each 6 rats) as follow: Subgroup (1): was kept without any treatment as a positive control (+ve group) and fed on basal diet.

Subgroups (2, 3 &4): were fed on basal diet containing 10% , 20% & 30 fennel seeds powder, respectively.

Results indicated that, oral rats with tramadol increased.

significantly all the previous parameters, except FI, BWG % , high density lipoprotein, superoxide dismutase (SOD) activity, total antioxidants and blood hemoglobin showed significant decrease compeded with all treated with levels of fennel seeds powder.

The present study recommended that consuming fennel seeds improved the symptoms of tramadol toxicity and prevent its complications.