Liver Enzymes Abnormalities among Highly Active Antiretroviral Therapy Experienced and HAART Naïve HIV-1 Infected Patients at Debre Tabor Hospital, North West Ethiopia: A Comparative Cross-Sectional Study
Joint Authors
Shiferaw, Melashu Balew
Tulu, Ketema Tafess
Zegeye, Amtatachew Moges
Wubante, Amarech Asratie
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Liver disease has emerged as the most common non-AIDS-related cause of death in HIV patients.
However, there is limited data regarding this condition including our setting in Ethiopia.
Hence, liver enzyme abnormalities among highly active antiretroviral therapy (HAART) experienced and HAART naïve patients were assessed in this study.
A total of 164 HAART experienced and 164 HAART naïve patients were studied.
Blood specimen was collected to determine alanine aminotransferase (ALT) and aspartate aminotransferase (AST), CD4 count, and viral hepatitis.
The prevalence of liver enzyme abnormality was 20.1% and 22.0% among HAART experienced and HAART naïve patients, respectively.
The HAART experienced patients had higher mean ALT than HAART naïve patients ( P = 0.002 ).
Viral hepatitis (AOR = 6.02; 95% CI = 1.87–19.39), opportunistic infections (AOR = 2.91; 95% CI = 1.04–8.19), current CD4 count <200 cells/mm3 (AOR = 2.16; 95% CI = 1.06–4.39), and male sex (AOR = 1.83; 95% CI = 1.001–3.33) were associated with elevated ALT and/or AST.
In conclusion, liver enzyme abnormalities were high in both HAART experienced and HAART naïve HIV-1 infected patients.
Hence, monitoring and management of liver enzyme abnormalities in HIV-1 infected patients are important in our setting.
American Psychological Association (APA)
Shiferaw, Melashu Balew& Tulu, Ketema Tafess& Zegeye, Amtatachew Moges& Wubante, Amarech Asratie. 2016. Liver Enzymes Abnormalities among Highly Active Antiretroviral Therapy Experienced and HAART Naïve HIV-1 Infected Patients at Debre Tabor Hospital, North West Ethiopia: A Comparative Cross-Sectional Study. AIDS Research and Treatment،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1096694
Modern Language Association (MLA)
Shiferaw, Melashu Balew…[et al.]. Liver Enzymes Abnormalities among Highly Active Antiretroviral Therapy Experienced and HAART Naïve HIV-1 Infected Patients at Debre Tabor Hospital, North West Ethiopia: A Comparative Cross-Sectional Study. AIDS Research and Treatment No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1096694
American Medical Association (AMA)
Shiferaw, Melashu Balew& Tulu, Ketema Tafess& Zegeye, Amtatachew Moges& Wubante, Amarech Asratie. Liver Enzymes Abnormalities among Highly Active Antiretroviral Therapy Experienced and HAART Naïve HIV-1 Infected Patients at Debre Tabor Hospital, North West Ethiopia: A Comparative Cross-Sectional Study. AIDS Research and Treatment. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1096694
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096694