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The CYBA Gene ⁎ 49A>G Polymorphism (rs7195830) Is Associated with Hypertension in Patients with Coronary Artery Disease
Joint Authors
Balcerzyk, Anna
Żak, Iwona
Iwanicki, Tomasz
Niemiec, Pawel
Nowak, Tomasz
Ochalska-Tyka, Anna
Krauze, Jolanta
Kosiorz-Gorczynska, Sylwia
Grzeszczak, Wladyslaw
Iwanicka, Joanna
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Purpose.
Single nucleotide polymorphisms of the CYBA gene may modify the risk of coronary artery disease (CAD).
The aim of the present study was to investigate whether the ⁎ 49A>G (rs7195830) polymorphism is associated with CAD.
Materials and Methods.
CYBA gene ⁎ 49A>G polymorphism was determined in 481 subjects: 242 patients with premature CAD and 239 age and sex matched controls using the fluorescently labeled allele-specific oligonucleotides method.
Results.
The frequency of the ⁎ 49G allele carrier state was significantly higher in patients than in controls (84.8% versus 76.6%, resp., P = 0.020 ), as well as the frequency of the ⁎ 49G allele (62.2% versus 54.0%, P = 0.009 ).
Both factors were associated with CAD in the analyzed population (OR = 1.70, 95% CI: 1.04–2.76 for GG+AG versus AA and OR = 1.40, 95% CI: 1.08–1.83 for ⁎ 49G versus ⁎ 49A).
Carrier state of the ⁎ 49G allele was a stronger and independent risk factor for CAD among women (OR = 4.35, 95% CI: 1.50–13.20, P = 0.002 ), as well as the ⁎ 49G allele (OR = 2.25, 95% CI: 1.34–3.77, P = 0.001 ).
The ⁎ 49G allele carrier state was also associated with left ventricular hypertrophy in patients with coronary artery disease ( P = 0.015 ).
Conclusion.
The CYBA gene ⁎ 49A>G polymorphism modifies the risk of coronary artery disease.
American Psychological Association (APA)
Nowak, Tomasz& Niemiec, Pawel& Kosiorz-Gorczynska, Sylwia& Balcerzyk, Anna& Iwanicki, Tomasz& Krauze, Jolanta…[et al.]. 2016. The CYBA Gene ⁎ 49A>G Polymorphism (rs7195830) Is Associated with Hypertension in Patients with Coronary Artery Disease. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1096909
Modern Language Association (MLA)
Nowak, Tomasz…[et al.]. The CYBA Gene ⁎ 49A>G Polymorphism (rs7195830) Is Associated with Hypertension in Patients with Coronary Artery Disease. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1096909
American Medical Association (AMA)
Nowak, Tomasz& Niemiec, Pawel& Kosiorz-Gorczynska, Sylwia& Balcerzyk, Anna& Iwanicki, Tomasz& Krauze, Jolanta…[et al.]. The CYBA Gene ⁎ 49A>G Polymorphism (rs7195830) Is Associated with Hypertension in Patients with Coronary Artery Disease. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1096909
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096909