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Wnt-β-Catenin Signaling Promotes the Maturation of Mast Cells
Joint Authors
Yamaguchi, Tomoko
Nishijima, Misae
Tashiro, Katsuhisa
Kawabata, Kenji
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Mast cells play an important role in the pathogenesis of allergic diseases.
Immature mast cells migrate into peripheral tissues from the bone marrow and undergo complete maturation.
Interestingly, mast cells have characteristics similar to hematopoietic stem cells (HSCs), such as self-renewal and c-kit expression.
In HSCs, Wnt signaling is involved in their maintenance and differentiation.
On the other hand, the relation between Wnt signaling and mast cell differentiation is poorly understood.
To study whether Wnt signals play a role in the maturation of mast cells, we studied the effect of Wnt proteins on mast cell maturation of bone marrow-derived mast cells (BMMCs).
The expression levels of CD81 protein and histidine decarboxylase mRNA and activity of mast cell-specific protease were all elevated in BMMCs treated with Wnt5a.
In addition, Wnt5a induced the expression of Axin2 and TCF mRNA in BMMCs.
These results showed that Wnt5a could promote the maturation of mast cells via the canonical Wnt signaling pathway and provide important insights into the molecular mechanisms underlying the differentiation of mast cells.
American Psychological Association (APA)
Yamaguchi, Tomoko& Nishijima, Misae& Tashiro, Katsuhisa& Kawabata, Kenji. 2016. Wnt-β-Catenin Signaling Promotes the Maturation of Mast Cells. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1097019
Modern Language Association (MLA)
Yamaguchi, Tomoko…[et al.]. Wnt-β-Catenin Signaling Promotes the Maturation of Mast Cells. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1097019
American Medical Association (AMA)
Yamaguchi, Tomoko& Nishijima, Misae& Tashiro, Katsuhisa& Kawabata, Kenji. Wnt-β-Catenin Signaling Promotes the Maturation of Mast Cells. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1097019
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097019