Enhanced Protective Effects of Combined Treatment with β-Carotene and Curcumin against Hyperthermic Spermatogenic Disorders in Mice
Joint Authors
Lin, Chunmei
Nam, Sang-Yoon
Choi, Yun Seok
Park, Seul Gi
Gwon, Lee Wha
Lee, Jong Geol
Yon, Jung-Min
Baek, In-Jeoung
Lee, Beom Jun
Yun, Young Won
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Scrotal hyperthermia leads to oxidative stress and apoptosis in spermatogenic cells, which subsequently causes male infertility.
In this study, we examined the effects of β-carotene and/or curcumin on heat-stress- (HS-) induced testicular injuries in mice.
ICR male mice (8 weeks old) were consecutively treated with β-carotene (10 mg/kg) and/or curcumin (20 mg/kg) orally once a day for 14 days and then subjected to single exposure with scrotal HS at 43°C for 15 min on day 7.
HS induced a significant reduction in testicular weight, appearance of multinucleated giant cells, and desquamation of germ cells in destructive seminiferous tubules, as well as degenerative Leydig cells.
Moreover, HS reduced the superoxide dismutase (SOD) activity and mRNA levels of mitochondrial SOD, phospholipid hydroperoxide glutathione peroxidase, B-cell lymphoma-extra-large, and 3β-hydroxysteroid dehydrogenase, with increases in lipid peroxidation levels and mRNA levels of BCL2-associated X protein and caspase-3 relative to those of the control group.
However, these changes were significantly recovered by combined treatment with β-carotene and curcumin after HS.
These findings indicate that the combined treatment with β-carotene and curcumin might be a valuable protective agent to ameliorate hyperthermic spermatogenic disorders via its potent antioxidative, antiapoptotic, and androgen synthetic effects.
American Psychological Association (APA)
Lin, Chunmei& Choi, Yun Seok& Park, Seul Gi& Gwon, Lee Wha& Lee, Jong Geol& Yon, Jung-Min…[et al.]. 2016. Enhanced Protective Effects of Combined Treatment with β-Carotene and Curcumin against Hyperthermic Spermatogenic Disorders in Mice. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1097105
Modern Language Association (MLA)
Lin, Chunmei…[et al.]. Enhanced Protective Effects of Combined Treatment with β-Carotene and Curcumin against Hyperthermic Spermatogenic Disorders in Mice. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1097105
American Medical Association (AMA)
Lin, Chunmei& Choi, Yun Seok& Park, Seul Gi& Gwon, Lee Wha& Lee, Jong Geol& Yon, Jung-Min…[et al.]. Enhanced Protective Effects of Combined Treatment with β-Carotene and Curcumin against Hyperthermic Spermatogenic Disorders in Mice. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1097105
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097105