Therapies for Prevention and Treatment of Alzheimer’s Disease
Joint Authors
Berumen, Laura Cristina
Mendiola-Precoma, J.
Padilla, K.
Garcia-Alcocer, G.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-28
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Alzheimer’s disease (AD) is the most common cause of dementia associated with a progressive neurodegenerative disorder, with a prevalence of 44 million people throughout the world in 2015, and this figure is estimated to double by 2050.
This disease is characterized by blood-brain barrier disruption, oxidative stress, mitochondrial impairment, neuroinflammation, and hypometabolism; it is related to amyloid-β peptide accumulation and tau hyperphosphorylation as well as a decrease in acetylcholine levels and a reduction of cerebral blood flow.
Obesity is a major risk factor for AD, because it induces adipokine dysregulation, which consists of the release of the proinflammatory adipokines and decreased anti-inflammatory adipokines, among other processes.
The pharmacological treatments for AD can be divided into two categories: symptomatic treatments such as acetylcholinesterase inhibitors and N-methyl-D-aspartate (NMDA) receptor antagonists and etiology-based treatments such as secretase inhibitors, amyloid binders, and tau therapies.
Strategies for prevention of AD through nonpharmacological treatments are associated with lifestyle interventions such as exercise, mental challenges, and socialization as well as caloric restriction and a healthy diet.
AD is an important health issue on which all people should be informed so that prevention strategies that minimize the risk of its development may be implemented.
American Psychological Association (APA)
Mendiola-Precoma, J.& Berumen, Laura Cristina& Padilla, K.& Garcia-Alcocer, G.. 2016. Therapies for Prevention and Treatment of Alzheimer’s Disease. BioMed Research International،Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1097113
Modern Language Association (MLA)
Mendiola-Precoma, J.…[et al.]. Therapies for Prevention and Treatment of Alzheimer’s Disease. BioMed Research International No. 2016 (2016), pp.1-17.
https://search.emarefa.net/detail/BIM-1097113
American Medical Association (AMA)
Mendiola-Precoma, J.& Berumen, Laura Cristina& Padilla, K.& Garcia-Alcocer, G.. Therapies for Prevention and Treatment of Alzheimer’s Disease. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1097113
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097113