Effect of High Dietary Tryptophan on Intestinal Morphology and Tight Junction Protein of Weaned Pig
Joint Authors
Tossou, Myrlene Carine B.
Liu, Hongnan
Bai, Miaomiao
Chen, Shuai
Cai, Yinghua
Duraipandiyan, Veeramuthu
Liu, Hongbin
Adebowale, Tolulope O.
Al-Dhabi, Naif Abdullah
Long, Lina
Tarique, Hussain
Oso, Abimbola O.
Yin, Yulong
Liu, Gang-yu
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Tryptophan (Trp) plays an essential role in pig behavior and growth performances.
However, little is known about Trp’s effects on tight junction barrier and intestinal health in weaned pigs.
In the present study, twenty-four (24) weaned pigs were randomly assigned to one of the three treatments with 8 piglets/treatments.
The piglets were fed different amounts of L-tryptophan (L-Trp) as follows: 0.0%, 0.15, and 0.75%, respectively, named zero Trp (ZTS), low Trp (LTS), and high Trp (HTS), respectively.
No significant differences were observed in average daily gain (ADG), average daily feed intake (ADFI), and gain: feed (G/F) ratio between the groups.
After 21 days of the feeding trial, results showed that dietary Trp significantly increased ( P < 0.05 ) crypt depth and significantly decreased ( P < 0.05 ) villus height to crypt depth ratio (VH/CD) in the jejunum of pig fed HTS.
In addition, pig fed HTS had higher ( P < 0.05 ) serum diamine oxidase (DAO) and D-lactate.
Furthermore, pig fed HTS significantly decreased mRNA expression of tight junction proteins occludin and ZO-1 but not claudin-1 in the jejunum.
The number of intraepithelial lymphocytes and goblet cells were not significantly different ( P > 0.05 ) between the groups.
Collectively, these data suggest that dietary Trp supplementation at a certain level (0.75%) may negatively affect the small intestinal structure in weaned pig.
American Psychological Association (APA)
Tossou, Myrlene Carine B.& Liu, Hongnan& Bai, Miaomiao& Chen, Shuai& Cai, Yinghua& Duraipandiyan, Veeramuthu…[et al.]. 2016. Effect of High Dietary Tryptophan on Intestinal Morphology and Tight Junction Protein of Weaned Pig. BioMed Research International،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1097190
Modern Language Association (MLA)
Tossou, Myrlene Carine B.…[et al.]. Effect of High Dietary Tryptophan on Intestinal Morphology and Tight Junction Protein of Weaned Pig. BioMed Research International No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1097190
American Medical Association (AMA)
Tossou, Myrlene Carine B.& Liu, Hongnan& Bai, Miaomiao& Chen, Shuai& Cai, Yinghua& Duraipandiyan, Veeramuthu…[et al.]. Effect of High Dietary Tryptophan on Intestinal Morphology and Tight Junction Protein of Weaned Pig. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1097190
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097190