β-Catenin Expression Negatively Correlates with WIF1 and Predicts Poor Clinical Outcomes in Patients with Cervical Cancer
Joint Authors
Liang, Jinxiao
Zhou, Hui
Peng, Yongpai
Xie, Xiaofei
Li, Ruixin
Liu, Yunyun
Xie, Qingsheng
Lin, Zhongqiu
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Aberrant activation of the canonical Wnt pathway plays a significant role in cervical cancer (CC).
However, limited data show the correlation between the cancer clinicopathological characteristics and the key molecules such as β-catenin and Wnt inhibitory factor 1 (WIF1).
In this study, β-catenin and WIF1 expression were analyzed by immunohistochemistry for 196 patients with CC, 39 with cervical intraepithelial neoplasia (CIN), and 41 with normal cervical epithelium (NCE).
Significant overexpression of β-catenin was detected in CC (67.9%) when compared to CIN (43.6%) or NCE (34.1%), p<0.01, while low WIF1 expression was detected in CC (24.0%) when compared to CIN (59.0%) or NCE (58.5%), p<0.001.
Negative correlation was shown between β-catenin and WIF1 expression (r=-0.637, p<0.001).
In addition, multivariate analysis revealed that both lymph node metastasis and β-catenin expression were the independent prognostic factors not only for disease-free survival (HR = 5.029, p<0.001; HR = 2.588, p=0.035, resp.), but also for overall survival (HR = 5.058, p<0.001; HR = 2.873, p=0.031, resp.).
Our findings indicate that, besides lymph node metastasis, β-catenin expression may also be a poor prognostic factor for CC while WIF1 could be a potential drug target for treatment of advanced CC.
American Psychological Association (APA)
Liang, Jinxiao& Zhou, Hui& Peng, Yongpai& Xie, Xiaofei& Li, Ruixin& Liu, Yunyun…[et al.]. 2016. β-Catenin Expression Negatively Correlates with WIF1 and Predicts Poor Clinical Outcomes in Patients with Cervical Cancer. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1097944
Modern Language Association (MLA)
Liang, Jinxiao…[et al.]. β-Catenin Expression Negatively Correlates with WIF1 and Predicts Poor Clinical Outcomes in Patients with Cervical Cancer. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1097944
American Medical Association (AMA)
Liang, Jinxiao& Zhou, Hui& Peng, Yongpai& Xie, Xiaofei& Li, Ruixin& Liu, Yunyun…[et al.]. β-Catenin Expression Negatively Correlates with WIF1 and Predicts Poor Clinical Outcomes in Patients with Cervical Cancer. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1097944
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097944