The Protective Effects of 18β-Glycyrrhetinic Acid on Helicobacter pylori-Infected Gastric Mucosa in Mongolian Gerbils

Joint Authors

Jiang, Jing
Cao, Donghui
You, Lili
Jia, Zhifang
Cai, Hongke
Wang, Shidong
Hou, Zhen
Suo, Yue-er
Cao, Xueyuan
Tsukamoto, Tetsuya

Source

BioMed Research International

Issue

Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-02-24

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Medicine

Abstract EN

18β-Glycyrrhetinic acid (GRA), a major component of Glycyrrhiza glabra, is widely used therapeutically in clinic.

In this study, the effect of GRA on Helicobacter pylori- (H.

pylori-) infected gastritis was investigated in Mongolian gerbils in vivo.

The gerbils were randomly divided into groups: uninfected; H.

pylori-infected; H.

pylori + antibiotics (clarithromycin, amoxicillin, and esomeprazole); and H.

pylori + GRA.

The gastric intraluminal pH value, histopathological changes, and the expression levels of inflammation-related cytokines (IL-1β, TNF-α, COX-2, and iNOS) were investigated.

The results showed that, in the H.

pylori + GRA group, the intraluminal gastric pH value was lower ( 2.14 ± 0.08 versus 3.17 ± 0.23 , P < 0.05 ), erosion and hyperplasia were alleviated, the infiltration of neutrophils and mononuclear cells was attenuated ( P < 0.05 ), and the expression levels of TNF-α, IL-1β, COX-2, and iNOS were decreased ( P < 0.05 ) compared with the H.

pylori-infected group.

There was no significant difference in results between the H.

pylori + GRA group and the H.

pylori + antibiotics group.

This study indicated that GRA significantly attenuated H.

pylori-infected gastritis in gerbils and has the potential to be developed as a new therapeutic drug.

American Psychological Association (APA)

Cao, Donghui& Jiang, Jing& You, Lili& Jia, Zhifang& Tsukamoto, Tetsuya& Cai, Hongke…[et al.]. 2016. The Protective Effects of 18β-Glycyrrhetinic Acid on Helicobacter pylori-Infected Gastric Mucosa in Mongolian Gerbils. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1097954

Modern Language Association (MLA)

Cao, Donghui…[et al.]. The Protective Effects of 18β-Glycyrrhetinic Acid on Helicobacter pylori-Infected Gastric Mucosa in Mongolian Gerbils. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1097954

American Medical Association (AMA)

Cao, Donghui& Jiang, Jing& You, Lili& Jia, Zhifang& Tsukamoto, Tetsuya& Cai, Hongke…[et al.]. The Protective Effects of 18β-Glycyrrhetinic Acid on Helicobacter pylori-Infected Gastric Mucosa in Mongolian Gerbils. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1097954

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1097954