L-Malate’s Plasma and Excretion Profile in the Treatment of Moderate and Severe Hemorrhagic Shock in Rats
Joint Authors
de Groot, Herbert
Rohrig, Ricarda
Waack, Indra N.
Himmen, Stephan
Mueller, Friederike
Roehrborn, Friederike
Teloh, Johanna K.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Introduction.
Malate is a standard component in fluid therapy within a wide range of medical applications.
To date, there are insufficient data regarding its plasma distribution, renal excretion, and metabolism after infusion.
This study aimed to investigate these three aspects in a rat model of moderate and severe hemorrhagic shock (HS).
Methods.
Male Wistar rats were subjected to HS by dropping the mean arterial blood pressure to 25–30 mmHg (severe) and 40–45 mmHg (moderate), respectively, for 60 minutes.
Subsequently, reperfusion with Ringer-saline or a malate containing crystalloid solution (7 mM, 13.6 mM, and 21 mM, resp.) was performed within 30 minutes, followed by an observation period of 150 minutes.
Results.
In the present experiments, malate rapidly disappeared from the blood, while only 5% of the infused malate was renally excreted.
In the resuscitation interval the urinary citrate and succinate amounts significantly increased compared to control.
Conclusion.
Malate’s half-life is between 30 and 60 minutes in both, moderate and severe HS.
Thus, even under traumatic conditions malate seems to be subjected to rapid metabolism with participation of the kidneys.
American Psychological Association (APA)
Waack, Indra N.& Himmen, Stephan& Mueller, Friederike& Rohrig, Ricarda& Roehrborn, Friederike& Teloh, Johanna K.…[et al.]. 2016. L-Malate’s Plasma and Excretion Profile in the Treatment of Moderate and Severe Hemorrhagic Shock in Rats. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098067
Modern Language Association (MLA)
Waack, Indra N.…[et al.]. L-Malate’s Plasma and Excretion Profile in the Treatment of Moderate and Severe Hemorrhagic Shock in Rats. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1098067
American Medical Association (AMA)
Waack, Indra N.& Himmen, Stephan& Mueller, Friederike& Rohrig, Ricarda& Roehrborn, Friederike& Teloh, Johanna K.…[et al.]. L-Malate’s Plasma and Excretion Profile in the Treatment of Moderate and Severe Hemorrhagic Shock in Rats. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098067
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098067