Prevalence of Extended Spectrum β-Lactamase and Antimicrobial Susceptibility Pattern of Clinical Isolates of Pseudomonas from Patients of Khyber Pakhtunkhwa, Pakistan
Joint Authors
Tariq, Imran
Ahmad, Manzoor
Hassan, Mukhtiar
Khalid, Anwar
Samad, Abdul
Mahmood, Qaisar
Murtaza, Ghulam
Mehmood, Rubada
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Majority of gram negative pathogenic bacteria are responsible for extended spectrum β-lactamases (ESBLs) production, which show resistance to some newer generation of antibiotics.
The study was aimed at evaluating the prevalence of ESBL and antibiotic susceptibility pattern of Pseudomonas isolates collected during 2010 to 2014 from tertiary care hospitals of Peshawar, Pakistan.
Out of 3450 samples, 334 Pseudomonas spp.
isolates comprised of 232 indoor and 102 outdoor patients were obtained from different specimens and their susceptibility pattern was determined against 20 antibiotics.
Antimicrobial susceptibility testing was carried out using the Kirby-Bauer agar diffusion method and ESBL production was detected by Synergy Disc Diffusion technique.
The mean age group of the patients was 29.9 + 9.15 years.
Meronem showed best activity (91.02%) from class carbapenem, β-lactam and β-lactamase inhibitors exhibited 69.16% activity, and doxycycline had a diminished activity (10.18%) to Pseudomonas spp.
Outdoor isolates were more resistant than the indoor and during the course of the study the sensitivity rate of antibiotics was gradually reducing.
ESBL production was observed in 44.32% while the remaining was non-ESBL.
The moderate active antibiotics were amikacin (50.7%), SCF (51.4%), TZP (52.7%), and MXF (54.1%) among ESBL producing isolates.
Lack of antibiotic policy, irrational uses (3GCs particularly), and the emergence of antibiotic resistant organisms in hospitals may be causes of high antibiotic resistance.
American Psychological Association (APA)
Ahmad, Manzoor& Hassan, Mukhtiar& Khalid, Anwar& Tariq, Imran& Mehmood, Rubada& Samad, Abdul…[et al.]. 2016. Prevalence of Extended Spectrum β-Lactamase and Antimicrobial Susceptibility Pattern of Clinical Isolates of Pseudomonas from Patients of Khyber Pakhtunkhwa, Pakistan. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1098362
Modern Language Association (MLA)
Ahmad, Manzoor…[et al.]. Prevalence of Extended Spectrum β-Lactamase and Antimicrobial Susceptibility Pattern of Clinical Isolates of Pseudomonas from Patients of Khyber Pakhtunkhwa, Pakistan. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1098362
American Medical Association (AMA)
Ahmad, Manzoor& Hassan, Mukhtiar& Khalid, Anwar& Tariq, Imran& Mehmood, Rubada& Samad, Abdul…[et al.]. Prevalence of Extended Spectrum β-Lactamase and Antimicrobial Susceptibility Pattern of Clinical Isolates of Pseudomonas from Patients of Khyber Pakhtunkhwa, Pakistan. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1098362
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098362