Aqueous Leaf Extract of Jatropha mollissima (Pohl) Bail Decreases Local Effects Induced by Bothropic Venom
Joint Authors
Lopes, Norberto Peporine
Fernandes, Júlia Morais
Zucolotto, Silvana Maria
Félix-Silva, Juliana
Gomes, Jacyra Antunes dos Santos
Geraldo Amaral, Juliano
Tabosa do Egito, Eryvaldo Sócrates
Fernandes-Pedrosa, Matheus de Freitas
Silva-Júnior, Arnóbio Antônio da
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-26
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Snakebites are a serious worldwide public health problem.
In Brazil, about 90% of accidents are attributed to snakes from the Bothrops genus.
The specific treatment consists of antivenom serum therapy, which has some limitations such as inability to neutralize local effects, difficult access in some regions, risk of immunological reactions, and high cost.
Thus, the search for alternative therapies to treat snakebites is relevant.
Jatropha mollissima (Euphorbiaceae) is a medicinal plant popularly used in folk medicine as an antiophidic remedy.
Therefore, this study aims to evaluate the effect of the aqueous leaf extract from J.
mollissima on local effects induced by Bothrops venoms.
High Performance Liquid Chromatography with Diode Array Detection analysis and Mass Spectrometry analysis of aqueous leaf extract confirmed the presence of the flavonoids isoschaftoside, schaftoside, isoorientin, orientin, vitexin, and isovitexin.
This extract, at 50–200 mg/kg doses administered by intraperitoneal route, showed significant inhibitory potential against local effects induced by Bothrops erythromelas and Bothrops jararaca snake venoms.
Local skin hemorrhage, local edema, leukocyte migration, and myotoxicity were significantly inhibited by the extract.
These results demonstrate that J.
mollissima extract possesses inhibitory potential, especially against bothropic venoms, suggesting its potential as an adjuvant in treatment of snakebites.
American Psychological Association (APA)
Gomes, Jacyra Antunes dos Santos& Félix-Silva, Juliana& Fernandes, Júlia Morais& Geraldo Amaral, Juliano& Lopes, Norberto Peporine& Tabosa do Egito, Eryvaldo Sócrates…[et al.]. 2016. Aqueous Leaf Extract of Jatropha mollissima (Pohl) Bail Decreases Local Effects Induced by Bothropic Venom. BioMed Research International،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1098392
Modern Language Association (MLA)
Gomes, Jacyra Antunes dos Santos…[et al.]. Aqueous Leaf Extract of Jatropha mollissima (Pohl) Bail Decreases Local Effects Induced by Bothropic Venom. BioMed Research International No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1098392
American Medical Association (AMA)
Gomes, Jacyra Antunes dos Santos& Félix-Silva, Juliana& Fernandes, Júlia Morais& Geraldo Amaral, Juliano& Lopes, Norberto Peporine& Tabosa do Egito, Eryvaldo Sócrates…[et al.]. Aqueous Leaf Extract of Jatropha mollissima (Pohl) Bail Decreases Local Effects Induced by Bothropic Venom. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1098392
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098392