Combinatorial Antitumor Effect of Rapamycin and β-Elemene in Follicular Thyroid Cancer Cells
Joint Authors
Zhu, Mei-fei
Zhou, Jun
He, Li-Li
Ding, Xiao-Fei
Yuan, Qiu-Qi
Zhang, Jian-Xin
Liu, Shuang-Chun
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
mTOR signaling would be a promising target for thyroid cancer therapy.
However, in clinical trials, objective response rate with mTOR inhibitor monotherapy in most cancer types was modest.
A new focus on development of combinatorial strategies with rapalogs is increasing.
Objective.
Investigating the combinatorial antitumor effect of rapamycin and β-elemene in follicular thyroid cancer cells.
Methods.
MTT assay was used to determine the FTC-133 cell proliferation after culturing with rapamycin and/or β-elemene.
To analyze their combinatorial effect, immunoblotting was performed to analyze the activation status of AKT.
Moreover, β-elemene attenuated rapamycin-induced immunosuppression was tested in mice.
Results.
Combination of rapamycin and β-elemene exerted significant synergistic antiproliferative effects in FTC-133 cell lines in vitro, based on inhibiting the AKT feedback activation induced by rapamycin.
In vivo, the β-elemene could attenuate rapamycin-induced immunosuppression via reversing imbalance of Treg/Th17, with the underlying mechanism needed to be declared.
Conclusions.
We demonstrate that the novel combination of mTOR inhibitor with β-elemene synergistically attenuates tumor cell growth in follicular thyroid cancer, which requires additional preclinical validation.
American Psychological Association (APA)
Zhou, Jun& He, Li-Li& Ding, Xiao-Fei& Yuan, Qiu-Qi& Zhang, Jian-Xin& Liu, Shuang-Chun…[et al.]. 2016. Combinatorial Antitumor Effect of Rapamycin and β-Elemene in Follicular Thyroid Cancer Cells. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098530
Modern Language Association (MLA)
Zhou, Jun…[et al.]. Combinatorial Antitumor Effect of Rapamycin and β-Elemene in Follicular Thyroid Cancer Cells. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1098530
American Medical Association (AMA)
Zhou, Jun& He, Li-Li& Ding, Xiao-Fei& Yuan, Qiu-Qi& Zhang, Jian-Xin& Liu, Shuang-Chun…[et al.]. Combinatorial Antitumor Effect of Rapamycin and β-Elemene in Follicular Thyroid Cancer Cells. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098530
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098530