Acoustic Cavitation Enhances Focused Ultrasound Ablation with Phase-Shift Inorganic Perfluorohexane Nanoemulsions: An In Vitro Study Using a Clinical Device
Joint Authors
Zhao, Lu-Yan
Zou, Jian-Zhong
Chen, Zong-Gui
Liu, Shan
Jiao, Jiao
Wu, Feng
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
To investigate whether acoustic cavitation could increase the evaporation of a phase-shift inorganic perfluorohexane (PFH) nanoemulsion and enhance high intensity focused ultrasound (HIFU) ablation.
Materials and Methods.
PFH was encapsulated by mesoporous silica nanocapsule (MSNC) to form a nanometer-sized droplet (MSNC-PFH).
It was added to a tissue-mimicking phantom, whereas phosphate buffered saline (PBS) was added as a control (PBS-control).
HIFU ( P a c = 15 0 W, t = 5 / 10 s) exposures were performed in both phantoms with various duty cycles (DC).
US images, temperature, and cavitation emissions were recorded during HIFU exposure.
HIFU-induced lesions were measured and calculated.
Results.
Compared to PBS-control, MSNC-PFH nanoemulsion could significantly increase the volume of HIFU-induced lesion ( P < 0.01 ).
Peak temperatures were 78.16 ± 5.64°C at a DC of 100%, 70.17 ± 6.43°C at 10%, 53.17 ± 4.54°C at 5%, and 42.00 ± 5.55°C at 2%, respectively.
Inertial cavitation was much stronger in the pulsed-HIFU than that in the continuous-wave HIFU exposure.
Compared to 100%-DC exposure, the mean volume of lesion induced by 5 s exposure at 10%-DC was significantly larger, but smaller at 2%-DC.
Conclusions.
MSNC-PFH nanoemulsion can significantly enhance HIFU ablation.
Appropriate pulsed-HIFU exposure could significantly increase the volume of lesion and reduce total US energy required for HIFU ablation.
American Psychological Association (APA)
Zhao, Lu-Yan& Zou, Jian-Zhong& Chen, Zong-Gui& Liu, Shan& Jiao, Jiao& Wu, Feng. 2016. Acoustic Cavitation Enhances Focused Ultrasound Ablation with Phase-Shift Inorganic Perfluorohexane Nanoemulsions: An In Vitro Study Using a Clinical Device. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098889
Modern Language Association (MLA)
Zhao, Lu-Yan…[et al.]. Acoustic Cavitation Enhances Focused Ultrasound Ablation with Phase-Shift Inorganic Perfluorohexane Nanoemulsions: An In Vitro Study Using a Clinical Device. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1098889
American Medical Association (AMA)
Zhao, Lu-Yan& Zou, Jian-Zhong& Chen, Zong-Gui& Liu, Shan& Jiao, Jiao& Wu, Feng. Acoustic Cavitation Enhances Focused Ultrasound Ablation with Phase-Shift Inorganic Perfluorohexane Nanoemulsions: An In Vitro Study Using a Clinical Device. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098889
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098889