Improvement in the Detection of Cystic Metastatic Papillary Thyroid Carcinoma by Measurement of Thyroglobulin in Aspirated Fluid
Joint Authors
Wang, Min-Jie
Zhang, Li
Zhang, Bin
Zhou, Chun-Wu
Guo, Hui-qin
Zhao, Huan
Wang, Yi-Xiang J.
Wang, Yong
Zhang, Zhi-hui
Jiang, Yu-Xin
Ahuja, Anil T.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Cystic change in metastatic lymph nodes of papillary thyroid carcinoma (PTC) is a diagnostic challenge for fine needle aspiration (FNA) because of the scant cellularity.
The aim of this study was to evaluate the measurement of thyroglobulin in fine needle aspirate (Tg-FNA) for detecting metastatic PTC in patients with cystic neck lesions and to validate the optimal cutoff value of Tg-FNA.
A total of 75 FNA specimens of cystic lesions were identified, including 40 of metastatic PTC.
Predetermined threshold levels of 0.04 (minimum detection level), 0.9, 10.0, and 77.0 ng/mL (maximum normal serum-Tg level) were used to evaluate the diagnostic accuracy of Tg-FNA for metastatic PTC detection.
The areas under the receiver operating characteristic curve for diagnosing metastatic PTC of Tg-FNA values of 0.04, 0.9, 10.0, and 77.0 ng/mL were 0.5 (95% confidence interval [CI], 0.382–0.618), 0.645 (95% CI, 0.526–0.752), 0.945 (95% CI, 0.866–0.984), and 0.973 (95% CI, 0.907–0.996), respectively.
With a cutoff value of 77.0 ng/mL, the combination of Tg-FNA and FNA cytology showed superior diagnostic power (97.5% sensitivity and 100% specificity) compared to FNA cytology alone (80% sensitivity and 100% specificity).
We recommend a Tg-FNA cutoff of 77.0 ng/mL, the maximum normal serum-Tg level, for cystic neck lesions.
American Psychological Association (APA)
Wang, Yong& Zhao, Huan& Wang, Yi-Xiang J.& Wang, Min-Jie& Zhang, Zhi-hui& Zhang, Li…[et al.]. 2016. Improvement in the Detection of Cystic Metastatic Papillary Thyroid Carcinoma by Measurement of Thyroglobulin in Aspirated Fluid. BioMed Research International،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1099157
Modern Language Association (MLA)
Wang, Yong…[et al.]. Improvement in the Detection of Cystic Metastatic Papillary Thyroid Carcinoma by Measurement of Thyroglobulin in Aspirated Fluid. BioMed Research International No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1099157
American Medical Association (AMA)
Wang, Yong& Zhao, Huan& Wang, Yi-Xiang J.& Wang, Min-Jie& Zhang, Zhi-hui& Zhang, Li…[et al.]. Improvement in the Detection of Cystic Metastatic Papillary Thyroid Carcinoma by Measurement of Thyroglobulin in Aspirated Fluid. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1099157
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099157