Computational Hemodynamic Analysis for the Diagnosis of Atherosclerotic Changes in Intracranial Aneurysms: A Proof-of-Concept Study Using 3 Cases Harboring Atherosclerotic and Nonatherosclerotic Aneurysms Simultaneously
Joint Authors
Ohta, M.
Sugiyama, Shin-ichiro
Endo, Hidenori
Niizuma, Kuniyasu
Endo, Toshiki
Funamoto, Kenichi
Tominaga, Teiji
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
This was a proof-of-concept computational fluid dynamics (CFD) study designed to identify atherosclerotic changes in intracranial aneurysms.
We selected 3 patients with multiple unruptured aneurysms including at least one with atherosclerotic changes and investigated whether an image-based CFD study could provide useful information for discriminating the atherosclerotic aneurysms.
Patient-specific geometries were constructed from three-dimensional data obtained using rotational angiography.
Transient simulations were conducted under patient-specific inlet flow rates measured by phase-contrast magnetic resonance velocimetry.
In the postanalyses, we calculated time-averaged wall shear stress (WSS), oscillatory shear index, and relative residence time (RRT).
The volume of blood flow entering aneurysms through the neck and the mean velocity of blood flow inside aneurysms were examined.
We applied the age-of-fluid method to quantitatively assess the residence of blood inside aneurysms.
Atherosclerotic changes coincided with regions exposed to disturbed blood flow, as indicated by low WSS and long RRT.
Blood entered aneurysms in phase with inlet flow rates.
The mean velocities of blood inside atherosclerotic aneurysms were lower than those inside nonatherosclerotic aneurysms.
Blood in atherosclerotic aneurysms was older than that in nonatherosclerotic aneurysms, especially near the wall.
This proof-of-concept study demonstrated that CFD analysis provided detailed information on the exchange and residence of blood that is useful for the diagnosis of atherosclerotic changes in intracranial aneurysms.
American Psychological Association (APA)
Sugiyama, Shin-ichiro& Endo, Hidenori& Niizuma, Kuniyasu& Endo, Toshiki& Funamoto, Kenichi& Ohta, M.…[et al.]. 2016. Computational Hemodynamic Analysis for the Diagnosis of Atherosclerotic Changes in Intracranial Aneurysms: A Proof-of-Concept Study Using 3 Cases Harboring Atherosclerotic and Nonatherosclerotic Aneurysms Simultaneously. Computational and Mathematical Methods in Medicine،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1100078
Modern Language Association (MLA)
Sugiyama, Shin-ichiro…[et al.]. Computational Hemodynamic Analysis for the Diagnosis of Atherosclerotic Changes in Intracranial Aneurysms: A Proof-of-Concept Study Using 3 Cases Harboring Atherosclerotic and Nonatherosclerotic Aneurysms Simultaneously. Computational and Mathematical Methods in Medicine No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1100078
American Medical Association (AMA)
Sugiyama, Shin-ichiro& Endo, Hidenori& Niizuma, Kuniyasu& Endo, Toshiki& Funamoto, Kenichi& Ohta, M.…[et al.]. Computational Hemodynamic Analysis for the Diagnosis of Atherosclerotic Changes in Intracranial Aneurysms: A Proof-of-Concept Study Using 3 Cases Harboring Atherosclerotic and Nonatherosclerotic Aneurysms Simultaneously. Computational and Mathematical Methods in Medicine. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1100078
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1100078