Tirofiban-Induced Thrombocytopenia Occurring with Crohn’s Disease

Abstract EN

A 69-year-old man, with severe refractory Crohn’s disease, presented with acute coronary syndrome that required angioplasty.

He developed severe tirofiban-induced thrombocytopenia (TIT) heralded by type I allergic reaction that required steroids and a combination of antihistamine H1 and antihistamine H2 for symptomatic management.

The thrombocytopenia spontaneously resolved uneventfully in 48 hours thereafter.

This case report suggests a possible association between TIT and inflammatory bowel disease.

Therefore, strict monitoring of the platelet count is required in patients who develop allergic reactions to tirofiban.