Treatment of Ipilimumab Induced Graves’ Disease in a Patient with Metastatic Melanoma
Joint Authors
Agrawal, Amit
Azmat, Umal
Liebner, David
Joehlin-Price, Amy
Nabhan, Fadi
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-11
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Objective.
Thyroid disease has been reported among the endocrinopathies that can occur after treatment with ipilimumab.
Graves’ disease, however, has been rarely reported with this medication.
Here we report a case of Graves’ disease diagnosed after initiation of ipilimumab in a patient with melanoma.
Methods.
We present the clinical presentation and management course of this patient followed by a related literature review.
Results.
A 67-year-old male with metastatic melanoma was started on ipilimumab.
He developed hyperthyroidism after two doses of ipilimumab.
The cause of hyperthyroidism was determined to be Graves’ disease.
Ipilimumab was held and the patient was started on methimazole with return to euthyroid status.
Ipilimumab was resumed and the patient continued methimazole during the course of ipilimumab therapy, with controlled hyperthyroidism.
Restaging studies following four cycles of ipilimumab showed complete response in the lungs, with residual melanoma in the neck.
The patient then underwent total thyroidectomy and left neck dissection as a definitive treatment for both hyperthyroidism and residual melanoma.
Conclusion.
Graves’ disease can develop after starting ipilimumab and methimazole can be an effective treatment.
For patients whose hyperthyroidism is well-controlled on methimazole, ipilimumab may be resumed with close monitoring.
American Psychological Association (APA)
Azmat, Umal& Liebner, David& Joehlin-Price, Amy& Agrawal, Amit& Nabhan, Fadi. 2016. Treatment of Ipilimumab Induced Graves’ Disease in a Patient with Metastatic Melanoma. Case Reports in Endocrinology،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1100672
Modern Language Association (MLA)
Azmat, Umal…[et al.]. Treatment of Ipilimumab Induced Graves’ Disease in a Patient with Metastatic Melanoma. Case Reports in Endocrinology No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1100672
American Medical Association (AMA)
Azmat, Umal& Liebner, David& Joehlin-Price, Amy& Agrawal, Amit& Nabhan, Fadi. Treatment of Ipilimumab Induced Graves’ Disease in a Patient with Metastatic Melanoma. Case Reports in Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1100672
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1100672